Literature DB >> 19457065

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal.

John Hardy1.   

Abstract

The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.

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Year:  2009        PMID： 19457065     DOI： 10.1111/j.1471-4159.2009.06181.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  265 in total

1.  Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.

Authors:  Lisa-Marie Munter; Anne Botev; Luise Richter; Peter W Hildebrand; Veit Althoff; Christoph Weise; Daniela Kaden; Gerd Multhaup
Journal:  J Biol Chem       Date:  2010-05-07       Impact factor: 5.157

2.  Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study.

Authors:  Lenore J Launer; Timothy M Hughes; Lon R White
Journal:  Ann Neurol       Date:  2011-11       Impact factor: 10.422

Review 3.  Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.

Authors:  Berislav V Zlokovic
Journal:  Nat Rev Neurosci       Date:  2011-11-03       Impact factor: 34.870

4.  BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice.

Authors:  Xiao-Xin Yan; Yan Cai; Xue-Mei Zhang; Xue-Gang Luo; Huaibin Cai; Gregory M Rose; Peter R Patrylo
Journal:  Exp Neurol       Date:  2012-01-11       Impact factor: 5.330

Review 5.  Nanopore analysis: An emerging technique for studying the folding and misfolding of proteins.

Authors:  Claudia Madampage; Omid Tavassoly; Chris Christensen; Meena Kumari; Jeremy S Lee
Journal:  Prion       Date:  2012-04-01       Impact factor: 3.931

6.  Fragment-guided approach to incorporating structural information into a CoMFA study: BACE-1 as an example.

Authors:  Lívia Barros Salum; Napoleão Fonseca Valadares
Journal:  J Comput Aided Mol Des       Date:  2010-07-27       Impact factor: 3.686

Review 7.  Current therapeutic targets for the treatment of Alzheimer's disease.

Authors:  Joshua D Grill; Jeffrey L Cummings
Journal:  Expert Rev Neurother       Date:  2010-05       Impact factor: 4.618

8.  An ECSIT-centric view of Alzheimer's disease.

Authors:  Mark P Mattson
Journal:  Bioessays       Date:  2012-05-29       Impact factor: 4.345

Review 9.  The neurodegeneration in Alzheimer disease and the prion protein.

Authors:  Gianluigi Forloni; Alessandra Sclip; Tiziana Borsello; Claudia Balducci
Journal:  Prion       Date:  2013-01-01       Impact factor: 3.931

10.  Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.

Authors:  Juliette Janson; Susanna Eketjäll; Karin Tunblad; Fredrik Jeppsson; Stefan Von Berg; Camilla Niva; Ann-Cathrin Radesäter; Johanna Fälting; Sandra A G Visser
Journal:  Pharm Res       Date:  2013-10-03       Impact factor: 4.200
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