Jessica H Kalmar1, Fei Wang2, Lara G Chepenik2, Fay Y Womer2, Monique M Jones2, Brian Pittman2, Maulik P Shah2, Andrés Martin2, R Todd Constable2, Hilary P Blumberg2. 1. Drs. Kalmar, Wang, Chepenik, Womer, Blumberg, and Shah are with the Yale School of Medicine and the Veterans Affairs Connecticut Healthcare System; Drs. Martin and Constable, and Ms. Jones and Mr. Pittman are with the Yale School of Medicine. Electronic address: jessica.kalmar@yale.edu. 2. Drs. Kalmar, Wang, Chepenik, Womer, Blumberg, and Shah are with the Yale School of Medicine and the Veterans Affairs Connecticut Healthcare System; Drs. Martin and Constable, and Ms. Jones and Mr. Pittman are with the Yale School of Medicine.
Abstract
OBJECTIVE: Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala in adolescents with bipolar disorder (BD). In the present study, structural and functional magnetic resonance imaging scans were obtained during the same neuroimaging session to examine amygdala structure-function relations in adolescents with BD. We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response. METHOD: Fifty-one adolescents (21 with BD I and 30 control adolescents, ages 10-18 years) underwent structural and functional magnetic resonance imaging scans. Amygdala volume (n = 49) and signal change (n = 44) during emotional face processing were compared between groups, and structure-function correlations were examined within the BD group (n = 16). RESULTS: Adolescents with BD showed decreased amygdala volume (p =.009) and increased amygdala response to emotional faces (p =.043). There was no significant interaction between diagnosis and emotion type. A significant inverse association between amygdala volume and activation during emotional face processing was observed (r = -0.54, p =.029). CONCLUSIONS: Decreased volume and increased response to emotional stimuli in the amygdala in adolescents with BD are consistent with previous reports. This study represents the first report, to our knowledge, of the two findings in the same adolescent BD sample and supports an amygdala structure-function relation characterized by an inverse association between volume and response to emotional stimuli. This preliminary finding requires replication and suggests a possible pathophysiological link between abnormalities in amygdala structure and response to emotional stimuli in BD.
OBJECTIVE: Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala in adolescents with bipolar disorder (BD). In the present study, structural and functional magnetic resonance imaging scans were obtained during the same neuroimaging session to examine amygdala structure-function relations in adolescents with BD. We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response. METHOD: Fifty-one adolescents (21 with BD I and 30 control adolescents, ages 10-18 years) underwent structural and functional magnetic resonance imaging scans. Amygdala volume (n = 49) and signal change (n = 44) during emotional face processing were compared between groups, and structure-function correlations were examined within the BD group (n = 16). RESULTS: Adolescents with BD showed decreased amygdala volume (p =.009) and increased amygdala response to emotional faces (p =.043). There was no significant interaction between diagnosis and emotion type. A significant inverse association between amygdala volume and activation during emotional face processing was observed (r = -0.54, p =.029). CONCLUSIONS: Decreased volume and increased response to emotional stimuli in the amygdala in adolescents with BD are consistent with previous reports. This study represents the first report, to our knowledge, of the two findings in the same adolescent BD sample and supports an amygdala structure-function relation characterized by an inverse association between volume and response to emotional stimuli. This preliminary finding requires replication and suggests a possible pathophysiological link between abnormalities in amygdala structure and response to emotional stimuli in BD.
Authors: Hilary P Blumberg; Nelson H Donegan; Charles A Sanislow; Susan Collins; Cheryl Lacadie; Pawel Skudlarski; Ralitza Gueorguieva; Robert K Fulbright; Thomas H McGlashan; John C Gore; John H Krystal Journal: Psychopharmacology (Berl) Date: 2005-10-26 Impact factor: 4.530
Authors: Yarema B Bezchlibnyk; Xiujun Sun; Jun-Feng Wang; Glenda M MacQueen; Bruce S McEwen; L Trevor Young Journal: J Psychiatry Neurosci Date: 2007-05 Impact factor: 6.186
Authors: Brendan A Rich; Deborah T Vinton; Roxann Roberson-Nay; Rebecca E Hommer; Lisa H Berghorst; Erin B McClure; Stephen J Fromm; Daniel S Pine; Ellen Leibenluft Journal: Proc Natl Acad Sci U S A Date: 2006-05-30 Impact factor: 11.205
Authors: Daniel P Dickstein; Michael P Milham; Allison C Nugent; Wayne C Drevets; Dennis S Charney; Daniel S Pine; Ellen Leibenluft Journal: Arch Gen Psychiatry Date: 2005-07
Authors: Isabelle M Rosso; Christina M Cintron; Ronald J Steingard; Perry F Renshaw; Ashley D Young; Deborah A Yurgelun-Todd Journal: Biol Psychiatry Date: 2005-01-01 Impact factor: 13.382
Authors: P V Choudary; M Molnar; S J Evans; H Tomita; J Z Li; M P Vawter; R M Myers; W E Bunney; H Akil; S J Watson; E G Jones Journal: Proc Natl Acad Sci U S A Date: 2005-10-17 Impact factor: 11.205
Authors: Hilary P Blumberg; Carolyn Fredericks; Fei Wang; Jessica H Kalmar; Linda Spencer; Xenophon Papademetris; Brian Pittman; Andres Martin; Bradley S Peterson; Robert K Fulbright; John H Krystal Journal: Bipolar Disord Date: 2005-12 Impact factor: 6.744
Authors: Erin E Edmiston; Fei Wang; Carolyn M Mazure; Joanne Guiney; Rajita Sinha; Linda C Mayes; Hilary P Blumberg Journal: Arch Pediatr Adolesc Med Date: 2011-12
Authors: Daniel P Dickstein; Cristina Gorrostieta; Hernando Ombao; Lisa D Goldberg; Alison C Brazel; Christopher J Gable; Clare Kelly; Dylan G Gee; Xi-Nian Zuo; F Xavier Castellanos; Michael P Milham Journal: Biol Psychiatry Date: 2010-08-24 Impact factor: 13.382
Authors: Jennifer A Sumner; Margaret A Sheridan; Stacy S Drury; Kyle C Esteves; Kate Walsh; Karestan C Koenen; Katie A McLaughlin Journal: J Child Adolesc Psychopharmacol Date: 2015-09-24 Impact factor: 2.576
Authors: Jens Foell; Isabella M Palumbo; James R Yancey; Nathalie Vizueta; Traute Demirakca; Christopher J Patrick Journal: Neuroimage Date: 2018-10-28 Impact factor: 6.556
Authors: Rebecca Kerestes; Zubin Bhagwagar; Pradeep J Nathan; Shashwath A Meda; Cecile D Ladouceur; Kathleen Maloney; David Matuskey; Barbara Ruf; Aybala Saricicek; Fei Wang; Godfrey D Pearlson; Mary L Phillips; Hilary P Blumberg Journal: Psychiatry Res Date: 2012-05-16 Impact factor: 3.222
Authors: Fei Wang; Jessica H Kalmar; Fay Y Womer; Erin E Edmiston; Lara G Chepenik; Rachel Chen; Linda Spencer; Hilary P Blumberg Journal: Brain Date: 2011-06-11 Impact factor: 13.501