CONTEXT: Several experimental studies have been carried out to explain the physiopathological mechanisms and to introduce endocrinological, enzymatic, biochemical and histopathological changes in organisms during acute pancreatitis. OBJECTIVE: To evaluate the effect of an intraperitoneal injection of melatonin on serum amylase levels. DESIGN: Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats. The rats were then divided into two groups: control and melatonin groups. INTERVENTION: The serum amylase level was measured on the 7th day after acute pancreatitis had developed. In the melatonin group, an intraperitoneal injection of melatonin (20 mg/kg/day) was performed starting from the 2(nd) day after pancreatic duct ligation. MAIN OUTCOME MEASURE: The levels of serum amylase were measured with an auto analyzer. RESULTS: It was found that the mean (+/-SD) level of serum amylase in the control group was 947+/-182 IU/mL while it was 358+/-177 IU/mL in the experimental group (P<0.001). CONCLUSIONS: The 20 mg/kg/day intraperitoneal injection of melatonin which was carried out for one week attenuated the serum amylase levels to a statistically significant degree. The researchers believe that intraperitoneal injections of melatonin decrease the severity of acute pancreatitis.
CONTEXT: Several experimental studies have been carried out to explain the physiopathological mechanisms and to introduce endocrinological, enzymatic, biochemical and histopathological changes in organisms during acute pancreatitis. OBJECTIVE: To evaluate the effect of an intraperitoneal injection of melatonin on serum amylase levels. DESIGN: Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats. The rats were then divided into two groups: control and melatonin groups. INTERVENTION: The serum amylase level was measured on the 7th day after acute pancreatitis had developed. In the melatonin group, an intraperitoneal injection of melatonin (20 mg/kg/day) was performed starting from the 2(nd) day after pancreatic duct ligation. MAIN OUTCOME MEASURE: The levels of serum amylase were measured with an auto analyzer. RESULTS: It was found that the mean (+/-SD) level of serum amylase in the control group was 947+/-182 IU/mL while it was 358+/-177 IU/mL in the experimental group (P<0.001). CONCLUSIONS: The 20 mg/kg/day intraperitoneal injection of melatonin which was carried out for one week attenuated the serum amylase levels to a statistically significant degree. The researchers believe that intraperitoneal injections of melatonin decrease the severity of acute pancreatitis.
Authors: Piotr J Czernik; Rachel M Golonka; Saroj Chakraborty; Beng San Yeoh; Ahmed A Abokor; Piu Saha; Ji-Youn Yeo; Blair Mell; Xi Cheng; Sudipta Baroi; Yuan Tian; Andrew D Patterson; Bina Joe; Matam Vijay-Kumar; Beata Lecka-Czernik Journal: Physiol Genomics Date: 2021-10-29 Impact factor: 3.107
Authors: Cristina Carrasco; María S Holguín-Arévalo; Gervasio Martín-Partido; Ana B Rodríguez; José A Pariente Journal: Mol Cell Biochem Date: 2013-11-15 Impact factor: 3.396
Authors: Jolanta Jaworek; Joanna Szklarczyk; Andrzej K Jaworek; Katarzyna Nawrot-Porąbka; Anna Leja-Szpak; Joanna Bonior; Michalina Kot Journal: Int J Inflam Date: 2012-04-23
Authors: Jolanta Jaworek; Anna Leja-Szpak; Katarzyna Nawrot-Porąbka; Joanna Szklarczyk; Michalina Kot; Piotr Pierzchalski; Marta Góralska; Piotr Ceranowicz; Zygmunt Warzecha; Artur Dembinski; Joanna Bonior Journal: Int J Mol Sci Date: 2017-05-08 Impact factor: 5.923