Literature DB >> 19454496

Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma.

Inga Nagel1, Takashi Akasaka, Wolfram Klapper, Stefan Gesk, Sebastian Böttcher, Matthias Ritgen, Lana Harder, Michael Kneba, Martin J S Dyer, Reiner Siebert.   

Abstract

In a subset of B-cell malignancies, the genes encoding members of the cyclin D familiy are juxtaposed to immunoglobulin loci through recurrent chromosomal translocations. Here, we identified the gene encoding cyclin E1 as novel translocation partner of the immunoglobulin heavy chain (IGH) locus involved in a t(14;19)(q32;q12) in a case of t(8;14)(q24;q32) IGH-MYC-positive leukemic diffuse large B-cell lymphoma. The translocation breakpoints were cloned and mapped to the switch region Salpha1 of IGH in 14q32 and approximately 60kb centromeric to CCNE1 in 19q12. Immunohistochemical analysis revealed overexpression of the cyclin E1 protein in this case, which to a comparable extent was observed in 3/41 independent DLBCL. These data indicate that cyclin E1 may act as a novel oncogene in B-cell lymphomagenesis.

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Year:  2009        PMID： 19454496      PMCID： PMC2704315          DOI： 10.3324/haematol.2008.000968

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  17 in total

1.  Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci.

Authors:  José I Martín-Subero; Lana Harder; Stefan Gesk; Brigitte Schlegelberger; Werner Grote; José A Martinez-Climent; Martin J S Dyer; Francisco J Novo; María J Calasanz; Reiner Siebert
Journal:  Int J Cancer       Date:  2002-03-20       Impact factor: 7.396

2.  Molecular-cytogenetic characterization of non-Hodgkin's lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene.

Authors:  Yumiko Kanda-Akano; Kenichi Nomura; Yasuko Fujita; Shigeo Horiike; Kazuhiro Nishida; Masami Nagai; Ikuo Miura; Shigeo Nakamura; Masao Seto; Shinsuke Iida; Ryuzo Ueda; Masafumi Taniwaki
Journal:  Leuk Lymphoma       Date:  2004-08

Review 3.  Cyclin E in normal and neoplastic cell cycles.

Authors:  Harry C Hwang; Bruce E Clurman
Journal:  Oncogene       Date:  2005-04-18       Impact factor: 9.867

Review 4.  Molecular features of B-cell lymphoma.

Authors:  R Siebert; A Rosenwald; L M Staudt; S W Morris
Journal:  Curr Opin Oncol       Date:  2001-09       Impact factor: 3.645

5.  Rapid amplification of immunoglobulin heavy chain switch (IGHS) translocation breakpoints using long-distance inverse PCR.

Authors:  T Sonoki; T G Willis; D G Oscier; E L Karran; R Siebert; M J S Dyer
Journal:  Leukemia       Date:  2004-12       Impact factor: 11.528

6.  Cyclin E overexpression and amplification in human tumours.

Authors:  Peter Schraml; Christoph Bucher; Heidi Bissig; Antonio Nocito; Philippe Haas; Kim Wilber; Steven Seelig; Juha Kononen; Michael J Mihatsch; Stefan Dirnhofer; Guido Sauter
Journal:  J Pathol       Date:  2003-07       Impact factor: 7.996

7.  Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray.

Authors:  Christine P Hans; Dennis D Weisenburger; Timothy C Greiner; Randy D Gascoyne; Jan Delabie; German Ott; H Konrad Müller-Hermelink; Elias Campo; Rita M Braziel; Elaine S Jaffe; Zenggang Pan; Pedro Farinha; Lynette M Smith; Brunangelo Falini; Alison H Banham; Andreas Rosenwald; Louis M Staudt; Joseph M Connors; James O Armitage; Wing C Chan
Journal:  Blood       Date:  2003-09-22       Impact factor: 22.113

Review 8.  Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

Authors:  J J M van Dongen; A W Langerak; M Brüggemann; P A S Evans; M Hummel; F L Lavender; E Delabesse; F Davi; E Schuuring; R García-Sanz; J H J M van Krieken; J Droese; D González; C Bastard; H E White; M Spaargaren; M González; A Parreira; J L Smith; G J Morgan; M Kneba; E A Macintyre
Journal:  Leukemia       Date:  2003-12       Impact factor: 11.528

9.  The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node.

Authors:  Martin Lodén; Maria Stighall; Niels Hilmer Nielsen; Göran Roos; Stefan O Emdin; Hanna Ostlund; Göran Landberg
Journal:  Oncogene       Date:  2002-07-11       Impact factor: 9.867

10.  A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.

Authors:  J I Martín-Subero; R Ibbotson; W Klapper; L Michaux; E Callet-Bauchu; F Berger; M J Calasanz; C De Wolf-Peeters; M J Dyer; P Felman; A Gardiner; R D Gascoyne; S Gesk; L Harder; D E Horsman; M Kneba; R Küppers; A Majid; N Parry-Jones; M Ritgen; M Salido; F Solé; G Thiel; H-H Wacker; D Oscier; I Wlodarska; R Siebert
Journal:  Leukemia       Date:  2007-05-10       Impact factor: 11.528
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  6 in total

1.  A new multicolor fluorescence in situ hybridization probe set directed against human heterochromatin: HCM-FISH.

Authors:  Maria Bucksch; Monika Ziegler; Nadezda Kosayakova; Milene V Mulatinho; Milene V Mulhatino; Juan C Llerena; Susanne Morlot; Wolfgang Fischer; Anna D Polityko; Anna I Kulpanovich; Michael B Petersen; Britta Belitz; Vladimir Trifonov; Anja Weise; Thomas Liehr; Ahmed B Hamid
Journal:  J Histochem Cytochem       Date:  2012-04-17       Impact factor: 2.479

2.  CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma.

Authors:  David Martín-Garcia; Alba Navarro; Rafael Valdés-Mas; Guillem Clot; Jesús Gutiérrez-Abril; Miriam Prieto; Inmaculada Ribera-Cortada; Renata Woroniecka; Grzegorz Rymkiewicz; Susanne Bens; Laurence de Leval; Andreas Rosenwald; Judith A Ferry; Eric D Hsi; Kai Fu; Jan Delabie; Dennis Weisenburger; Daphne de Jong; Fina Climent; Sheila J O'Connor; Steven H Swerdlow; David Torrents; Sergi Beltran; Blanca Espinet; Blanca González-Farré; Luis Veloza; Dolors Costa; Estella Matutes; Reiner Siebert; German Ott; Leticia Quintanilla-Martinez; Elaine S Jaffe; Carlos López-Otín; Itziar Salaverria; Xose S Puente; Elias Campo; Sílvia Beà
Journal:  Blood       Date:  2018-12-11       Impact factor: 22.113

3.  Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma.

Authors:  Sietse M Aukema; Markus Kreuz; Christian W Kohler; Maciej Rosolowski; Dirk Hasenclever; Michael Hummel; Ralf Küppers; Dido Lenze; German Ott; Christiane Pott; Julia Richter; Andreas Rosenwald; Monika Szczepanowski; Carsten Schwaenen; Harald Stein; Heiko Trautmann; Swen Wessendorf; Lorenz Trümper; Markus Loeffler; Rainer Spang; Philip M Kluin; Wolfram Klapper; Reiner Siebert
Journal:  Haematologica       Date:  2013-10-31       Impact factor: 9.941

Review 4.  The role of aberrant proteolysis in lymphomagenesis.

Authors:  Anagh A Sahasrabuddhe; Kojo S J Elenitoba-Johnson
Journal:  Curr Opin Hematol       Date:  2015-07       Impact factor: 3.284

5.  Tumor suppressor function of miR-483-3p on breast cancer via targeting of the cyclin E1 gene.

Authors:  Xiaoxi Huang; Jin Lyu
Journal:  Exp Ther Med       Date:  2018-07-23       Impact factor: 2.447

6.  Validation of break-apart and fusion MYC probes using a digital fluorescence in situ hybridization capture and imaging system.

Authors:  Michael Liew; Leslie Rowe; Parker W Clement; Rodney R Miles; Mohamed E Salama
Journal:  J Pathol Inform       Date:  2016-05-04
  6 in total

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