Literature DB >> 19454344

Influenza A virus TRIMs the type I interferon response.

Stephan Ludwig, Thorsten Wolff.   

Abstract

The virulence of many pathogenic viruses depends on suppression of the innate type I interferon defense. For influenza viruses, a unique strategy has now been unraveled, as the viral nonstructural protein 1 was shown to inhibit activation of the pathogen recognition receptor RIG-I by binding the ubiquitin ligase TRIM25.

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Year:  2009        PMID： 19454344     DOI： 10.1016/j.chom.2009.05.004

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  7 in total

1.  Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1.

Authors:  Joseph J Jablonski; Dipwanita Basu; Daniel A Engel; H Mario Geysen
Journal:  Bioorg Med Chem       Date:  2011-10-19       Impact factor: 3.641

2.  Interferon Inducer IFI35 regulates RIG-I-mediated innate antiviral response through mutual antagonism with Influenza protein NS1.

Authors:  Hui Yang; Wendy Winkler; Xiaopeng Wu
Journal:  J Virol       Date:  2021-03-10       Impact factor: 5.103

3.  Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner.

Authors:  Marcin P Walkiewicz; Dipanwita Basu; Joseph J Jablonski; H Mario Geysen; Daniel A Engel
Journal:  J Gen Virol       Date:  2010-09-29       Impact factor: 3.891

Review 4.  Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and currently available drugs.

Authors:  R Gasparini; D Amicizia; P L Lai; N L Bragazzi; D Panatto
Journal:  J Prev Med Hyg       Date:  2014-09

Review 5.  Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis.

Authors:  Jung Min Shim; Jinhee Kim; Tanel Tenson; Ji-Young Min; Denis E Kainov
Journal:  Viruses       Date:  2017-08-12       Impact factor: 5.048

Review 6.  The TRIMendous Role of TRIMs in Virus-Host Interactions.

Authors:  Sarah van Tol; Adam Hage; Maria Isabel Giraldo; Preeti Bharaj; Ricardo Rajsbaum
Journal:  Vaccines (Basel)       Date:  2017-08-22

7.  Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus.

Authors:  Yong Ma; Jiashan Sun; Linlin Gu; Hongmei Bao; Yuhui Zhao; Lin Shi; Wei Yao; Guobin Tian; Xiurong Wang; Hualan Chen
Journal:  BMC Microbiol       Date:  2017-09-11       Impact factor: 3.605
  7 in total

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