| Literature DB >> 19454277 |
Sandeepa M Eswarappa1, Jessin Janice, Sudhagar V Balasundaram, Narendra M Dixit, Dipshikha Chakravortty.
Abstract
In this study, we have identified the possible genetic factors responsible for fowl-adaptation of Salmonella entericaserovar Gallinarum (S. Gallinarum). By comparing the genes related to Salmonella pathogenicity islands (SPI) of S. Gallinarum with those of Salmonella entericaserovar Enteritidis (S. Enteritidis) we have identified twenty-four positively selected genes. Our results suggest that the genes encoding the structural components of SPI-2 encoded type three secretion apparatus (TTSS) and the effector proteins that are secreted via SPI-1 encoded TTSS have evolved under positive selection pressure in these serovars. We propose that these positively selected genes play important roles in conferring different host-specificities to S. Gallinarum and S. Enteritidis.Entities:
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Year: 2009 PMID： 19454277 DOI： 10.1016/j.meegid.2009.01.004
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342