| Literature DB >> 19453159 |
Gonçalo Graça1, Iola F Duarte, António S Barros, Brian J Goodfellow, Sílvia Diaz, Isabel M Carreira, Ana Bela Couceiro, Eulália Galhano, Ana M Gil.
Abstract
An NMR-metabonomic study of malformed fetuses was carried out through human amniotic fluid (HAF) analysis. Over 70 compounds were detected in control HAF by NMR. Possible confounding variables (fetus gender and gestational and maternal ages) were shown not to induce detectable compositional trends in the control group considered. Malformed fetuses showed variations in glucose, some amino acids and organic acids and proteins. In tandem with enzymatic assays, these NMR results suggest that changes in gycolysis and gluconeogenesis as well as kidney underdevelopment occur in the malformed fetuses studied here.Entities:
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Year: 2009 PMID： 19453159 DOI： 10.1021/pr900386f
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466