| Literature DB >> 19452310 |
Alexandra Germanová1, Anna Germanová, Petra Tesarová, Marie Jáchymová, Karel Zvára, Tomás Zima, Marta Kalousová.
Abstract
Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P< 0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis.Entities:
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Year: 2009 PMID： 19452310 DOI： 10.1080/07357900802350822
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176