| Literature DB >> 19450510 |
Raghu R Chivukula1, Joshua T Mendell.
Abstract
MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.Entities:
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Year: 2009 PMID: 19450510 DOI: 10.1016/j.cell.2009.04.059
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582