Multiperturbation analysis of distributed neural networks: the case of spatial neglect.

This study assesses the feasibility of using a multiperturbation analysis (MPA) approach for lesion-symptom mapping. We analyze the relative contribution of damage in different brain regions to the expression of spatial neglect, as revealed in line-bisection performance. The data set comprised of normalized lesion information and bisection test results from 23 first-event right-hemisphere stroke patients. Obtaining quantitative measures of task relevance for different regions of interest (ROIs), the following ROIs were found to be the most contributing: the supramarginal and angular gyri of the inferior parietal lobule, the superior parietal lobule, the anterior part of the temporo-parietal junction connecting the superior temporal and supramarginal gyri, and the thalamus. MPA is likely to play an important role in elucidating the anatomical substrate of complex functions.