Literature DB >> 19449125

Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene.

Zhisheng Zhang1, Delin Mo, Peiqing Cong, Zuyong He, Fei Ling, Anning Li, Yuna Niu, Xiao Zhao, Chunyan Zhou, Yaosheng Chen.   

Abstract

The product of transmembrane and coiled-coil domains 1 (TMCO1) gene is a member of DUF841 superfamily of several eukaryotic proteins with unknown function. The partial DNA sequence of porcine TMCO1 was first cloned with a pig 567 bp ORF encoding 188 amino acids. By tissues expression analysis, the TMCO1 was found highly expressed in the liver, kidney and heart. The porcine TMCO1 protein was subsequently demonstrated to localize in the mitochondrion by confocal fluorescence microscopy. This data provides an important basis for conducing further studies on the functions and regulatory mechanisms underlying the role of TMCO1 gene.

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Year:  2009        PMID： 19449125     DOI： 10.1007/s11033-009-9573-8

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  34 in total

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