Literature DB >> 19448395

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

Mikhail V Blagosklonny1.   

Abstract

Here I overview the accompanying three reports on suppression of cellular senescence with inhibitors of mTOR, PI-3K and MEK. How can growth inhibitors suppress senescence? May these aging-suppressants decelerate organismal aging? To answer these questions, we need to reconsider the meaning of aging.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19448395     DOI： 10.4161/cc.8.12.8815

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  34 in total

1.  Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.

Authors:  Tatiana V Pospelova; Tatiana V Bykova; Svetlana G Zubova; Natalia V Katolikova; Natalia M Yartzeva; Valery A Pospelov
Journal:  Cell Cycle       Date:  2013-12-02       Impact factor: 4.534

2.  Fasting levels of hepatic p-S6 are increased in old mice.

Authors:  Olga V Leontieva; Geraldine M Paszkiewicz; Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 3.  Rapalogs in cancer prevention: anti-aging or anticancer?

Authors:  Mikhail V Blagosklonny
Journal:  Cancer Biol Ther       Date:  2012-11-14       Impact factor: 4.742

4.  Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.

Authors:  Stephen L Abrams; Linda S Steelman; John G Shelton; William Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
Journal:  Cell Cycle       Date:  2010-05-15       Impact factor: 4.534

5.  The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy.

Authors:  Stephen L Abrams; Linda S Steelman; John G Shelton; Ellis W T Wong; William H Chappell; Jörg Bäsecke; Franca Stivala; Marco Donia; Ferdinando Nicoletti; Massimo Libra; Alberto M Martelli; James A McCubrey
Journal:  Cell Cycle       Date:  2010-05-10       Impact factor: 4.534

6.  Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.

Authors:  Linda S Steelman; Patrick Navolanic; William H Chappell; Stephen L Abrams; Ellis W T Wong; Alberto M Martelli; Lucio Cocco; Franca Stivala; Massimo Libra; Ferdinando Nicoletti; Lyudmyla B Drobot; Richard A Franklin; James A McCubrey
Journal:  Cell Cycle       Date:  2011-09-01       Impact factor: 4.534

7.  Ser2481-autophosphorylated mTOR colocalizes with chromosomal passenger proteins during mammalian cell cytokinesis.

Authors:  Alejandro Vazquez-Martin; Tamara Sauri-Nadal; Octavio J Menendez; Cristina Oliveras-Ferraros; Sílvia Cufí; Bruna Corominas-Faja; Eugeni López-Bonet; Javier A Menendez
Journal:  Cell Cycle       Date:  2012-10-24       Impact factor: 4.534

8.  Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential.

Authors:  Zoya N Demidenko; Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2009-12-31       Impact factor: 5.682

9.  Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.

Authors:  Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2010-04-18       Impact factor: 5.682

10.  Pseudo-DNA damage response in senescent cells.

Authors:  Tatyana V Pospelova; Zoya N Demidenko; Elena I Bukreeva; Valery A Pospelov; Andrei V Gudkov; Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2009-12-01       Impact factor: 4.534
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.