RATIONALE: Identification of the minimal ozone (O(3)) concentration and/or dose that induces measurable lung function decrements in humans is considered in the risk assessment leading to establishing an appropriate National Ambient Air Quality Standard for O(3) that protects public health. OBJECTIVES: To identify and/or predict the minimal mean O(3) concentration that produces a decrement in FEV(1) and symptoms in healthy individuals completing 6.6-hour exposure protocols. METHODS: Pulmonary function and subjective symptoms were measured in 31 healthy adults (18-25 yr, male and female, nonsmokers) who completed five 6.6-hour chamber exposures: filtered air and four variable hourly patterns with mean O(3) concentrations of 60, 70, 80, and 87 parts per billion (ppb). MEASUREMENTS AND MAIN RESULTS: Compared with filtered air, statistically significant decrements in FEV(1) and increases in total subjective symptoms scores (P < 0.05) were measured after exposure to mean concentrations of 70, 80, and 87 ppb O(3). The mean percent change in FEV(1) (+/-standard error) at the end of each protocol was 0.80 +/- 0.90, -2.72 +/- 1.48, -5.34 +/- 1.42, -7.02 +/- 1.60, and -11.42 +/- 2.20% for exposure to filtered air and 60, 70, 80, and 87 ppb O(3), respectively. CONCLUSIONS: Inhalation of 70 ppb O(3) for 6.6 hours, a concentration below the current 8-hour National Ambient Air Quality Standard of 75 ppb, is sufficient to induce statistically significant decrements in FEV(1) in healthy young adults.
RATIONALE: Identification of the minimal ozone (O(3)) concentration and/or dose that induces measurable lung function decrements in humans is considered in the risk assessment leading to establishing an appropriate National Ambient Air Quality Standard for O(3) that protects public health. OBJECTIVES: To identify and/or predict the minimal mean O(3) concentration that produces a decrement in FEV(1) and symptoms in healthy individuals completing 6.6-hour exposure protocols. METHODS: Pulmonary function and subjective symptoms were measured in 31 healthy adults (18-25 yr, male and female, nonsmokers) who completed five 6.6-hour chamber exposures: filtered air and four variable hourly patterns with mean O(3) concentrations of 60, 70, 80, and 87 parts per billion (ppb). MEASUREMENTS AND MAIN RESULTS: Compared with filtered air, statistically significant decrements in FEV(1) and increases in total subjective symptoms scores (P < 0.05) were measured after exposure to mean concentrations of 70, 80, and 87 ppb O(3). The mean percent change in FEV(1) (+/-standard error) at the end of each protocol was 0.80 +/- 0.90, -2.72 +/- 1.48, -5.34 +/- 1.42, -7.02 +/- 1.60, and -11.42 +/- 2.20% for exposure to filtered air and 60, 70, 80, and 87 ppb O(3), respectively. CONCLUSIONS: Inhalation of 70 ppb O(3) for 6.6 hours, a concentration below the current 8-hour National Ambient Air Quality Standard of 75 ppb, is sufficient to induce statistically significant decrements in FEV(1) in healthy young adults.
Authors: Victor C Van Hee; Joel D Kaufman; G R Scott Budinger; Gökhan M Mutlu Journal: Am J Respir Crit Care Med Date: 2010-06-01 Impact factor: 21.405
Authors: Benjamin Wells; Heather Simon; Thomas J Luben; Zachary Pekar; Scott M Jenkins Journal: Air Qual Atmos Health Date: 2019-03-07 Impact factor: 3.763
Authors: Zhuowei Li; Robert M Tighe; Feifei Feng; Julie G Ledford; John W Hollingsworth Journal: J Biochem Mol Toxicol Date: 2012-11-20 Impact factor: 3.642
Authors: Brian D Moore; Dallas M Hyde; Lisa A Miller; Emily M Wong; Edward S Schelegle Journal: Am J Respir Cell Mol Biol Date: 2014-07 Impact factor: 6.914
Authors: Chong S Kim; Neil E Alexis; Ana G Rappold; Howard Kehrl; Milan J Hazucha; John C Lay; Mike T Schmitt; Martin Case; Robert B Devlin; David B Peden; David Diaz-Sanchez Journal: Am J Respir Crit Care Med Date: 2011-01-07 Impact factor: 21.405
Authors: Adelaide Tovar; Gregory J Smith; Joseph M Thomas; Wesley L Crouse; Jack R Harkema; Samir N P Kelada Journal: Toxicol Sci Date: 2020-01-01 Impact factor: 4.849