Literature DB >> 19447621

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.

Suvi Rajamaki1, Anna Innitzer, Chiara Falciani, Cristina Tintori, Frauke Christ, Myriam Witvrouw, Zeger Debyser, Silvio Massa, Maurizio Botta.   

Abstract

A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.

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Year:  2009        PMID： 19447621     DOI： 10.1016/j.bmcl.2009.04.132

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  In Silico Drug Discovery for Treatment of Virus Diseases.

Authors:  Shikha Joon; Rajeev K Singla; Bairong Shen
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

Review 2.  Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.

Authors:  Michael A McCoy; Dominique Spicer; Neil Wells; Kurt Hoogewijs; Marc Fiedler; Matthias G J Baud
Journal:  J Med Chem       Date:  2022-05-17       Impact factor: 8.039

3.  New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Authors:  Solene Guiheneuf; Ludovic Paquin; François Carreaux; Emilie Durieu; Thierry Roisnel; Laurent Meijer; Jean-Pierre Bazureau
Journal:  Mol Divers       Date:  2014-03-02       Impact factor: 2.943

4.  Characterization of a novel anti-cancer compound for astrocytomas.

Authors:  Sang Y Lee; Becky Slagle-Webb; Elias Rizk; Akshal Patel; Patti A Miller; Shen-Shu Sung; James R Connor
Journal:  PLoS One       Date:  2014-09-25       Impact factor: 3.240

Review 5.  Recent pharmacological developments on rhodanines and 2,4-thiazolidinediones.

Authors:  Ravinder Singh Bhatti; Sakshi Shah; Pawan Krishan; Jagir S Sandhu
Journal:  Int J Med Chem       Date:  2013-05-02

6.  Synthesis and Antibacterial Evaluation of (S,Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)Pentanoic Acids.

Authors:  Ming-Xia Song; Xian-Qing Deng; Zhi-Yu Wei; Chang-Ji Zheng; Yan Wu; Chang-Shan An; Hu-Ri Piao
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

7.  Synthesis and antibacterial activity of new (2,4-dioxothiazolidin-5-yl/ylidene)acetic acid derivatives with thiazolidine-2,4-dione, rhodanine and 2-thiohydantoin moieties.

Authors:  Nazar Trotsko; Urszula Kosikowska; Agata Paneth; Monika Wujec; Anna Malm
Journal:  Saudi Pharm J       Date:  2018-02-02       Impact factor: 4.330

8.  Design and Synthesis of Aza-/Oxa Heterocycle-Based Conjugates as Novel Anti-Inflammatory Agents Targeting Cyclooxygenase-2.

Authors:  Sukhmeet Kaur; Priya Kumari; Gurjit Singh; Rajbir Bhatti; Palwinder Singh
Journal:  ACS Omega       Date:  2018-05-30

9.  Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies.

Authors:  Mohsinul Mulk Bacha; Humaira Nadeem; Sumera Zaib; Sadia Sarwar; Aqeel Imran; Shafiq Ur Rahman; Hafiz Saqib Ali; Muazzam Arif; Jamshed Iqbal
Journal:  BMC Chem       Date:  2021-04-27

10.  In silico virtual screening approaches for anti-viral drug discovery.

Authors:  Manuela S Murgueitio; Marcel Bermudez; Jérémie Mortier; Gerhard Wolber
Journal:  Drug Discov Today Technol       Date:  2012
  10 in total

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