BACKGROUND: We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts. OBJECTIVES: We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans in the Atherosclerosis Risk in Communities (ARIC) Study. METHODS: PA self-reported at baseline and images from cerebral MRI examination obtained 6 years later were evaluated for presence and location of subclinical infarcts > or = 3 mm in size. After exclusions, 944 participants were eligible for study. RESULTS: The results suggested an inverse relationship between odds of having a subclinical cerebral infarct and level of PA on several measures, although the multivariable adjusted odds ratios (OR) were statistically significant only for the sport score. A 1-unit increase in the sport score, indicating more leisure PA, was associated with an adjusted OR for having a subclinical cerebral infarct of 0.62 (0.44-0.87), with a statistically significant monotonic trend across quartiles of the score (P = 0.01). There was no association of work scores with subclinical infarcts. CONCLUSIONS: In African-Americans, sport PA was inversely related to subclinical MRI-detected cerebral infarcts assessed six years later.
BACKGROUND: We hypothesized that physical activity (PA), which is often associated with reduced risk of ischemic stroke, may also be associated with reduced risk of subclinical cerebral infarcts. OBJECTIVES: We studied the cross-sectional association between PA and subclinical cerebral infarcts among African-Americans in the Atherosclerosis Risk in Communities (ARIC) Study. METHODS: PA self-reported at baseline and images from cerebral MRI examination obtained 6 years later were evaluated for presence and location of subclinical infarcts > or = 3 mm in size. After exclusions, 944 participants were eligible for study. RESULTS: The results suggested an inverse relationship between odds of having a subclinical cerebral infarct and level of PA on several measures, although the multivariable adjusted odds ratios (OR) were statistically significant only for the sport score. A 1-unit increase in the sport score, indicating more leisure PA, was associated with an adjusted OR for having a subclinical cerebral infarct of 0.62 (0.44-0.87), with a statistically significant monotonic trend across quartiles of the score (P = 0.01). There was no association of work scores with subclinical infarcts. CONCLUSIONS: In African-Americans, sport PA was inversely related to subclinical MRI-detected cerebral infarcts assessed six years later.
Authors: M Yoshita; E Fletcher; D Harvey; M Ortega; O Martinez; D M Mungas; B R Reed; C S DeCarli Journal: Neurology Date: 2006-12-26 Impact factor: 9.910
Authors: William L Haskell; I-Min Lee; Russell R Pate; Kenneth E Powell; Steven N Blair; Barry A Franklin; Caroline A Macera; Gregory W Heath; Paul D Thompson; Adrian Bauman Journal: Med Sci Sports Exerc Date: 2007-08 Impact factor: 5.411
Authors: J M Burns; B B Cronk; H S Anderson; J E Donnelly; G P Thomas; A Harsha; W M Brooks; R H Swerdlow Journal: Neurology Date: 2008-07-15 Impact factor: 9.910
Authors: Véronique L Roger; Alan S Go; Donald M Lloyd-Jones; Robert J Adams; Jarett D Berry; Todd M Brown; Mercedes R Carnethon; Shifan Dai; Giovanni de Simone; Earl S Ford; Caroline S Fox; Heather J Fullerton; Cathleen Gillespie; Kurt J Greenlund; Susan M Hailpern; John A Heit; P Michael Ho; Virginia J Howard; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Diane M Makuc; Gregory M Marcus; Ariane Marelli; David B Matchar; Mary M McDermott; James B Meigs; Claudia S Moy; Dariush Mozaffarian; Michael E Mussolino; Graham Nichol; Nina P Paynter; Wayne D Rosamond; Paul D Sorlie; Randall S Stafford; Tanya N Turan; Melanie B Turner; Nathan D Wong; Judith Wylie-Rosett Journal: Circulation Date: 2010-12-15 Impact factor: 29.690