| Literature DB >> 19446615 |
Junju Xu1, Hong Yu, Chen Qing, Yanli Zhang, Ying Liu, Yegao Chen.
Abstract
Two new dimeric phenanthrenes, bulbophythrins A (1) and B (2), were isolated from Bulbophyllum odoratissimum. Their structures were elucidated by HR-ESI-MS, 1D and 2DNMR spectroscopy. They were evaluated in vitro for their inhibitory ability against the growth of human leukemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer SGC-7901. Both compounds showed significant cytotoxicity against the tested cell lines. Compound 1 exhibited some selectivity against HL-60 and BEL-7402 with IC(50) values of 1.27 x 10(-3) and 1.22 x 10(-3) micromol/ml respectively, whereas 2 was most active against A549 with IC(50) value of 1.18 x 10(-3) micromol/ml.Entities:
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Year: 2009 PMID： 19446615 DOI： 10.1016/j.fitote.2009.05.007
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882