| Literature DB >> 19446591 |
Wei-Ying Zhou1, Yun Shi, Chao Wu, Wei-Jun Zhang, Xu-Hu Mao, Gang Guo, Hai-Xia Li, Quan-Ming Zou.
Abstract
Epitope vaccine is a promising option for therapeutic vaccination against Helicobacter pylori (H. pylori) infection. In this study, we constructed a multi-epitope vaccine with five epitopes and mucosal adjuvant E. coli heat-labile enterotoxin B subunit (LTB) named HUepi-LTB and evaluated its therapeutic effect against H. pylori infection in BALB/c mice model. HUepi-LTB containing three Th epitopes from UreB and two B cell epitopes from UreB and HpaA was constructed and expressed in E. coli. Oral therapeutic immunization with HUepi-LTB significantly decreased H. pylori colonization compared with oral immunization with PBS, and the protection was correlated with antigen-specific CD4+ T cells and IgG and mucosal IgA antibody responses. This multi-epitope vaccine may be a promising vaccine candidate that may help to control H. pylori infection.Entities:
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Year: 2009 PMID： 19446591 DOI： 10.1016/j.vaccine.2009.05.009
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641