Literature DB >> 19445469

Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana.

Pietro Morlacchi1, William K Wilson, Quanbo Xiong, Aparna Bhaduri, Diana Sttivend, Mariya D Kolesnikova, Seiichi P T Matsuda.   

Abstract

The triterpene product profile is reported for At5g36150 (PEN3), the last unexamined oxidosqualene cyclase in the reference plant Arabidopsis thaliana. PEN3 makes tirucalla-7,24-dien-3beta-ol ( approximately 85%) and several minor products. Also discussed are the unexpectedly facile convergent evolution of another Arabidopsis tirucalladienol synthase (LUP5), mechanistic origins of the 20S configuration, and active-site remodeling necessary to accommodate the 17alpha side chain. This work marks the first completed functional characterization of all triterpene synthases in a higher plant.

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Year:  2009        PMID： 19445469     DOI： 10.1021/ol9005745

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Opaciniols A-C, new terpenoids from Garcinia opaca.

Authors:  Reika Mori; Alfarius Eko Nugroho; Yusuke Hirasawa; Chin Piow Wong; Toshio Kaneda; Osamu Shirota; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2013-03-28       Impact factor: 2.343

2.  Biotic elicitors enhance diosgenin production in Helicteres isora L. suspension cultures via up-regulation of CAS and HMGR genes.

Authors:  Samrin Shaikh; Varsha Shriram; Tushar Khare; Vinay Kumar
Journal:  Physiol Mol Biol Plants       Date:  2020-02-20

3.  Distinct triterpene synthases in the laticifers of Euphorbia lathyris.

Authors:  Edith Forestier; Carmen Romero-Segura; Irini Pateraki; Emilio Centeno; Vincent Compagnon; Myriam Preiss; Anne Berna; Albert Boronat; Thomas J Bach; Sylvain Darnet; Hubert Schaller
Journal:  Sci Rep       Date:  2019-03-18       Impact factor: 4.379

4.  A conserved mechanism affecting hydride shifting and deprotonation in the synthesis of hopane triterpenes as compositions of wax in oat.

Authors:  Miaomiao Liang; Fan Zhang; Jiaxin Xu; Xiaoning Wang; Ruibo Wu; Zheyong Xue
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-15       Impact factor: 12.779

5.  Identification of early quassinoid biosynthesis in the invasive tree of heaven (Ailanthus altissima) confirms evolutionary origin from protolimonoids.

Authors:  Ling Chuang; Shenyu Liu; Dave Biedermann; Jakob Franke
Journal:  Front Plant Sci       Date:  2022-08-23       Impact factor: 6.627

6.  Comparative Transcriptome Analysis Identifies Putative Genes Involved in Steroid Biosynthesis in Euphorbia tirucalli.

Authors:  Weibo Qiao; Changfu Li; Isidore Mosongo; Qin Liang; Mengdi Liu; Xin Wang
Journal:  Genes (Basel)       Date:  2018-01-15       Impact factor: 4.096

7.  Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production.

Authors:  Hannah Hodgson; Ricardo De La Peña; Michael J Stephenson; Ramesha Thimmappa; Jason L Vincent; Elizabeth S Sattely; Anne Osbourn
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-01       Impact factor: 12.779

8.  An Independent Evolutionary Origin for Insect Deterrent Cucurbitacins in Iberis amara.

Authors:  Lemeng Dong; Aldo Almeida; Jacob Pollier; Bekzod Khakimov; Jean-Etienne Bassard; Karel Miettinen; Dan Stærk; Rahimi Mehran; Carl Erik Olsen; Mohammed Saddik Motawia; Alain Goossens; Søren Bak
Journal:  Mol Biol Evol       Date:  2021-10-27       Impact factor: 16.240
  8 in total

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