| Literature DB >> 19444958 |
Lei Chen1, Changjin Liu, Lieju Liu.
Abstract
The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4-/- mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways.Entities:
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Year: 2009 PMID： 19444958 PMCID： PMC2775522 DOI： 10.1016/j.neulet.2009.01.022
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046