Literature DB >> 194449

Effects of ACTH and dexamethasone on the zona glomerulosa of the rat adrenal cortex: an ultrastructural stereologic study.

G G Nussdorfer, G Mazzocchi, C Robba, A S Belloni, P Rebuffat.   

Abstract

The effects of a chronic treatment with ACTH and dexamethasone on the zona glomerulosa of intact rat adrenals were investigated by morphometric methods and electron microscopy. It was found that ACTH increases the volume of the zona glomerulosa, of the cells, nuclei mitochondrial compartment as well as the surface of SER and mitochondrial compartment as well as the surface of SER and mitochondrial cristae. Also noticeable was the hypertrophy of the Golgi apparatus. Opposite effects were obtained after dexamethasone treatment. These findings are interpreted as indicating that ACTH is involved in the maintenance and stimulation of the growth and steroidogenic capacity of the adrenal zona glomerulosa.

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Year:  1977        PMID： 194449     DOI： 10.1530/acta.0.0850608

Source DB:  PubMed          Journal:  Acta Endocrinol (Copenh)        ISSN： 0001-5598


  5 in total

1.  The influence of dexamethasone treatment of pregnant rats on the development of chromaffin tissue in their offspring during the fetal and neonatal period.

Authors:  M Manojlivić; M Hristić; D Kalafatić; B Plećas; N Ugresić
Journal:  J Endocrinol Invest       Date:  1998-04       Impact factor: 4.256

2.  Stereological and functional investigations on isolated adrenocortical cells. III. Zona glomerulosa cells of chronically ACTH-treated rats.

Authors:  P G Andreis; G Neri; P Rebuffat; G Gottardo; G Mazzocchi; G G Nussdorfer
Journal:  J Anat       Date:  1990-02       Impact factor: 2.610

3.  Investigations on the turnover of adrenocortical mitochondria. XV. A stereological study of the effect of chronic treatment with angiotensin II on the size and number of the mitochondria in the zona glomerulosa of the rat.

Authors:  G Mazzocchi; C Robba; P Rebuffat; G G Nussdorfer
Journal:  Cell Tissue Res       Date:  1980       Impact factor: 5.249

4.  Short- and long-term effects of ACTH on the adrenal zona glomerulosa of the rat. A coupled stereological and enzymological study.

Authors:  G Mazzocchi; L K Malendowicz; P Rebuffat; C Robba; G Gottardo; G G Nussdorfer
Journal:  Cell Tissue Res       Date:  1986       Impact factor: 5.249

5.  A stereological study of the trophic effects of the renin-angiotensin system on the rat adrenal zona glomerulosa.

Authors:  P Rebuffat; A S Belloni; G Mazzocchi; P Vassanelli; G G Nussdorfer
Journal:  J Anat       Date:  1979-10       Impact factor: 2.610
  5 in total

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