Literature DB >> 19444877

Development and persistence of posttraumatic stress disorder and the 5-HTTLPR polymorphism.

Geeta A Thakur1, Ridha Joober, Alain Brunet.   

Abstract

Association between 5-HTTLPR polymorphism and development of acute and persistence of chronic posttraumatic stress disorder (PTSD) was prospectively investigated. DNA was extracted from 41 motor-vehicle accident victims evaluated for development and persistence of PTSD, 1 and 12 months posttrauma. At Time 1, a nonsignificant trend for higher acute PTSD rate in ll homozygotes (82%) was observed compared to those with ss and sl genotypes (50%). At Time 2, higher chronic PTSD rate was found in ll homozygotes (55%) compared to those with ss and sl genotypes (20%), with an odds ratio of 4.8 (95% CI = 1.09-21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5-HTTLPR in chronic PTSD.

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Year:  2009        PMID： 19444877     DOI： 10.1002/jts.20405

Source DB:  PubMed          Journal:  J Trauma Stress        ISSN： 0894-9867


  14 in total

1.  The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism.

Authors:  Zhewu Wang; Dewleen G Baker; Judith Harrer; Mark Hamner; Matthew Price; Ananda Amstadter
Journal:  Depress Anxiety       Date:  2011-08-04       Impact factor: 6.505

2.  Associations between the SS variant of 5-HTTLPR and PTSD among adults with histories of childhood emotional abuse: results from two African American independent samples.

Authors:  Kate Walsh; Monica Uddin; Richelo Soliven; Derek E Wildman; Bekh Bradley
Journal:  J Affect Disord       Date:  2014-03-12       Impact factor: 4.839

Review 3.  A consideration of select pre-trauma factors as key vulnerabilities in PTSD.

Authors:  Jessica Bomyea; Victoria Risbrough; Ariel J Lang
Journal:  Clin Psychol Rev       Date:  2012-07-20

Review 4.  Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies.

Authors:  Marilyn C Cornelis; Nicole R Nugent; Ananda B Amstadter; Karestan C Koenen
Journal:  Curr Psychiatry Rep       Date:  2010-08       Impact factor: 5.285

5.  SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder.

Authors:  Karestan C Koenen; Monica Uddin; Shun-Chiao Chang; Allison E Aiello; Derek E Wildman; Emily Goldmann; Sandro Galea
Journal:  Depress Anxiety       Date:  2011-05-23       Impact factor: 6.505

6.  Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response.

Authors:  Anett Mueller; Diana Armbruster; Dirk A Moser; Turhan Canli; Klaus-Peter Lesch; Burkhard Brocke; Clemens Kirschbaum
Journal:  Neuropsychopharmacology       Date:  2011-03-02       Impact factor: 7.853

Review 7.  Animal models for posttraumatic stress disorder: An overview of what is used in research.

Authors:  Bart Borghans; Judith R Homberg
Journal:  World J Psychiatry       Date:  2015-12-22

Review 8.  Genetic approaches to understanding post-traumatic stress disorder.

Authors:  Lynn M Almli; Negar Fani; Alicia K Smith; Kerry J Ressler
Journal:  Int J Neuropsychopharmacol       Date:  2013-10-08       Impact factor: 5.176

Review 9.  Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.

Authors:  Sumeet Sharma; Abigail Powers; Bekh Bradley; Kerry J Ressler
Journal:  Annu Rev Psychol       Date:  2015-10-06       Impact factor: 24.137

10.  Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: a pilot study.

Authors:  Robert H Pietrzak; Sandro Galea; Steven M Southwick; Joel Gelernter
Journal:  J Affect Disord       Date:  2012-11-24       Impact factor: 4.839
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