OBJECTIVES: The aim of this pilot study was to explore possible ultrasound parameters for the early detection of alcohol-mediated fetal somatic and central nervous system (CNS) maldevelopment. Maternal alcohol ingestion during pregnancy may lead to fetal alcohol spectrum disorders (FASD), which encompass a broad range of structural abnormalities including growth impairment, specific craniofacial features and CNS abnormalities. Early detection of fetuses at risk of FASD would support earlier interventions. METHODS: We performed a longitudinal prospective pilot study from 2004 to 2006 at two sites in Ukraine. A sample of pregnant women who reported consuming moderate-to-heavy amounts of alcohol participated in a comprehensive maternal interview, and received ultrasound evaluation of fetal growth and specific fetal brain measurements during the second and third trimesters. These measurements were compared with those collected from a group of pregnant women who consumed little-to-no alcohol during pregnancy, and who were recruited and followed in the same manner. RESULTS: From 6745 screened women, 84 moderate-to-heavy alcohol users and 82 comparison women were identified and ultrasound examinations performed. After controlling for maternal smoking, alcohol-exposed fetuses had shorter mean femur length, caval-calvarial distance and frontothalamic measurements in the second trimester (P < 0.05), and alcohol-exposed fetuses also had shorter frontothalamic distance measurements in the third trimester relative to comparison fetuses (P < 0.05). In addition, after controlling for maternal smoking, both mean orbital diameter and biparietal diameter measurements were significantly smaller on average in the alcohol-exposed group in the third trimester relative to comparison fetuses (P < 0.05). CONCLUSIONS: Significant differences in selected somatic and brain measurements were noted between alcohol-exposed and comparison fetuses, suggesting these markers may be further explored for clinical utility in prenatal identification of affected children. Further study correlating these findings with alcohol-related physical features of the newborn and subsequent comparisons of neuro-developmental outcomes will help define potential uses of prenatal ultrasound for intervention and prevention of FASD. (c) 2009 ISUOG.
OBJECTIVES: The aim of this pilot study was to explore possible ultrasound parameters for the early detection of alcohol-mediated fetal somatic and central nervous system (CNS) maldevelopment. Maternal alcohol ingestion during pregnancy may lead to fetal alcohol spectrum disorders (FASD), which encompass a broad range of structural abnormalities including growth impairment, specific craniofacial features and CNS abnormalities. Early detection of fetuses at risk of FASD would support earlier interventions. METHODS: We performed a longitudinal prospective pilot study from 2004 to 2006 at two sites in Ukraine. A sample of pregnant women who reported consuming moderate-to-heavy amounts of alcohol participated in a comprehensive maternal interview, and received ultrasound evaluation of fetal growth and specific fetal brain measurements during the second and third trimesters. These measurements were compared with those collected from a group of pregnant women who consumed little-to-no alcohol during pregnancy, and who were recruited and followed in the same manner. RESULTS: From 6745 screened women, 84 moderate-to-heavy alcohol users and 82 comparison women were identified and ultrasound examinations performed. After controlling for maternal smoking, alcohol-exposed fetuses had shorter mean femur length, caval-calvarial distance and frontothalamic measurements in the second trimester (P < 0.05), and alcohol-exposed fetuses also had shorter frontothalamic distance measurements in the third trimester relative to comparison fetuses (P < 0.05). In addition, after controlling for maternal smoking, both mean orbital diameter and biparietal diameter measurements were significantly smaller on average in the alcohol-exposed group in the third trimester relative to comparison fetuses (P < 0.05). CONCLUSIONS: Significant differences in selected somatic and brain measurements were noted between alcohol-exposed and comparison fetuses, suggesting these markers may be further explored for clinical utility in prenatal identification of affected children. Further study correlating these findings with alcohol-related physical features of the newborn and subsequent comparisons of neuro-developmental outcomes will help define potential uses of prenatal ultrasound for intervention and prevention of FASD. (c) 2009 ISUOG.
Authors: Nancy S Handmaker; William F Rayburn; Chen Meng; Jordan B Bell; Brittany B Rayburn; Valerie J Rappaport Journal: Alcohol Clin Exp Res Date: 2006-05 Impact factor: 3.455
Authors: M Russell; S S Martier; R J Sokol; P Mudar; S Bottoms; S Jacobson; J Jacobson Journal: Alcohol Clin Exp Res Date: 1994-10 Impact factor: 3.455
Authors: Shonagh K O'Leary-Moore; Scott E Parnell; Elizabeth A Godin; Deborah B Dehart; Jacob J Ament; Amber A Khan; G Allan Johnson; Martin A Styner; Kathleen K Sulik Journal: Birth Defects Res A Clin Mol Teratol Date: 2010-09-14
Authors: Scott E Parnell; Hunter E Holloway; Lorinda K Baker; Martin A Styner; Kathleen K Sulik Journal: Alcohol Clin Exp Res Date: 2014-06-13 Impact factor: 3.455
Authors: Julie A Kable; Claire D Coles; Kenneth L Jones; Lyubov Yevtushok; Yaroslav Kulikovsky; Wladimir Wertelecki; Christina D Chambers Journal: Alcohol Clin Exp Res Date: 2016-09-21 Impact factor: 3.455
Authors: Elizabeth A Godin; Shonagh K O'Leary-Moore; Amber A Khan; Scott E Parnell; Jacob J Ament; Deborah B Dehart; Brice W Johnson; G Allan Johnson; Martin A Styner; Kathleen K Sulik Journal: Alcohol Clin Exp Res Date: 2009-10-23 Impact factor: 3.455
Authors: Annika C Montag; Andrew D Hull; Lyubov Yevtushok; Natalya Zymak-Zakutnya; Zoryana Sosyniuk; Viktor Dolhov; Kenneth Lyons Jones; Wladimir Wertelecki; Christina D Chambers Journal: Alcohol Clin Exp Res Date: 2016-09-30 Impact factor: 3.455
Authors: Scott E Parnell; Hunter T Holloway; Shonagh K O'Leary-Moore; Deborah B Dehart; Beatriz Paniaqua; Ipek Oguz; Francois Budin; Martin A Styner; G Allan Johnson; Kathleen K Sulik Journal: Neurotoxicol Teratol Date: 2013-07-30 Impact factor: 3.763