Literature DB >> 19444696

Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.

Ann B Ragin1, Ying Wu, Renee Ochs, Rachel Scheidegger, Bruce A Cohen, Justin C McArthur, Leon G Epstein, Katherine Conant.   

Abstract

Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.

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Year:  2009        PMID： 19444696      PMCID： PMC3469319          DOI： 10.1080/13550280902913271

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  32 in total

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  10 in total

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