Literature DB >> 19444269

Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?

Yuen Fei Wong1, Qihe Xu2.   

Abstract

The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho(-/-) mice following genetic inactivation of 1alpha-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho(-/-) mice.

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Year:  2009        PMID: 19444269     DOI: 10.1038/ki.2009.55

Source DB:  PubMed          Journal:  Kidney Int        ISSN: 0085-2538            Impact factor:   10.612


  2 in total

Review 1.  The virtues of vitamin D--but how much is too much?

Authors:  Rukshana Shroff; Craig Knott; Lesley Rees
Journal:  Pediatr Nephrol       Date:  2010-09       Impact factor: 3.714

2.  Reply to W.B. Grant 'Re: Vitamin D deficiency among northern Native Peoples'.

Authors:  Peter Frost
Journal:  Int J Circumpolar Health       Date:  2012-04-24       Impact factor: 1.228

  2 in total

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