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Literature DB >> 19443931

Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.

Abstract

This review briefly summarizes the information on the molecular mechanisms of action, pharmacokinetic profiles and drug interactions of novel (third-generation) antiepileptic drugs, including brivaracetam, carabersat, carisbamate, DP-valproic acid, eslicarbazepine, fluorofelbamate, fosphenytoin, ganaxolone, lacosamide, losigamone, pregabalin, remacemide, retigabine, rufinamide, safinamide, seletracetam, soretolide, stiripentol, talampanel, and valrocemide. These novel antiepileptic drugs undergo intensive clinical investigations to assess their efficacy and usefulness in the treatment of patients with refractory epilepsy.

Entities: Disease Species

Mesh：

Substances：
Anticonvulsants

Year: 2009 PMID： 19443931 DOI： 10.1016/s1734-1140(09)70024-6

Source DB: PubMed Journal: Pharmacol Rep ISSN： 1734-1140 Impact factor: 3.024

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Cited

35 in total

Review 1. Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy.

Authors: Emma D Deeks
Journal: CNS Drugs Date: 2011-10-01 Impact factor: 5.749

2. Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats.

Authors: Luis F Pacheco Otalora; Frank Skinner; Mauro S Oliveira; Bianca Farrell; Massoud F Arshadmansab; Tarun Pandari; Ileana Garcia; Leslie Robles; Gerardo Rosas; Carlos F Mello; Boris S Ermolinsky; Emilio R Garrido-Sanabria
Journal: Brain Res Date: 2010-10-21 Impact factor: 3.252

Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.

Review 1. Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy.

2. Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats.

Review 3. Animal models of Parkinson's disease: a gateway to therapeutics?

Review 4. G protein-coupled receptors in acquired epilepsy: Druggability and translatability.

Review 5. Pharmacotherapy of epilepsy: newly approved and developmental agents.

6. Synthesis of new tricyclic imidazotriazepine derivatives condensed with various heterocycles.

7. Retigabine (ezogabine) as add-on therapy for partial-onset seizures: an update for clinicians.

8. Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications.

9. The safety of lacosamide for treatment of seizures and seizure prophylaxis in adult hospitalized patients.

10. Enhancing KCNQ Channel Activity Improves Neurobehavioral Recovery after Spinal Cord Injury.