| Literature DB >> 19443217 |
Alexandre V Ivachtchenko1, Eugene B Frolov, Oleg D Mitkin, Volodymyr M Kysil, Alexander V Khvat, Ilya M Okun, Sergey E Tkachenko.
Abstract
Synthesis, biological evaluation and structure-activity relationships for a series of novel gamma-carboline analogues of Dimebon are described. Among the studied compounds, gamma-carbolines 3{8} and 3{14} have been identified as potent small molecule antagonists of histamine H(1) (IC(50)=0.1 microM) and serotonin 5-HT(6) (IC(50)=0.37 microM) receptors, respectively.Entities:
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Year: 2009 PMID： 19443217 DOI： 10.1016/j.bmcl.2009.04.128
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823