| Literature DB >> 19442569 |
Cheng-Jun Zhou1, Xun Qu, Yong-Mei Yang, Fu-Fang Wang, Zuo-Qing Dong, Cheng-Qin Wang, Xiao-Ying Zhang, Gui-Xiang Liu, Feng-Cai Wei, Shan-Zhen Sun.
Abstract
To investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its effects on angiogenesis and lymphangiogenesis in oral carcinoma. Immunohistochemistry was used to study the expression of CEACAM1, LYVE1 and CD31, double-labelling immunofluorescence was used to detect the co-expression of CEACAM1 and LYVE1, and double-labelling immunohistochemistry was performed to observe the co-expression of LYVE1 and CD31 in vessels. Membranous CEACAM1 was expressed in well-differentiated squamous cell carcinoma and cytoplastic CEACAM1 in poorly and moderately differentiated carcinoma (P<0.05). More CEACAM1-positive vessels were observed in CEACAM1-positive tumors with cytoplasmic expression than with membranous expression (P<0.001). Co-expression of CEACAM1 and LYVE1, LYVE1 and CD31 in vessels was more common in CEACAM1-positive tumors with cytoplasmic expression than with membranous expression (P<0.001). CEACAM1 has different distribution in oral carcinoma. Membranous CEACAM1 inhibits angiogenesis and lymphangiogenesis, but cytoplasmic CEACAM1 promotes angiogenesis, and even promotes lymphangiogenesis by mediating the transformation of vascular endothelial cells (VECs) into lymphatic endothelial cells (LECs).Entities:
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Year: 2009 PMID： 19442569 DOI： 10.1016/j.oraloncology.2009.03.002
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337