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Literature DB >> 19442435

Cannabinoids in the treatment of cancer.

Amy Alexander¹, Paul F Smith, Rhonda J Rosengren.

Abstract

Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB(1) and CB(2)) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results.

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Year: 2009 PMID： 19442435 DOI： 10.1016/j.canlet.2009.04.005

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

39 in total

1. Mistic and TarCF as fusion protein partners for functional expression of the cannabinoid receptor 2 in Escherichia coli.

Authors: Ananda Chowdhury; Rentian Feng; Qin Tong; Yuxun Zhang; Xiang-Qun Xie
Journal: Protein Expr Purif Date: 2012-03-03 Impact factor: 1.650

2. Cannabinoids attenuate cancer pain and proliferation in a mouse model.

Authors: Negin Saghafi; David K Lam; Brian L Schmidt
Journal: Neurosci Lett Date: 2010-11-19 Impact factor: 3.046

3. Revisiting CB1 receptor as drug target in human melanoma.

Authors: István Kenessey; Balázs Bánki; Agnes Márk; Norbert Varga; József Tóvári; Andrea Ladányi; Erzsébet Rásó; József Tímár
Journal: Pathol Oncol Res Date: 2012-03-24 Impact factor: 3.201

4. Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

Authors: Claudia Mugnaini; Stefania Nocerino; Valentina Pedani; Serena Pasquini; Andrea Tafi; Maria De Chiaro; Luca Bellucci; Massimo Valoti; Francesca Guida; Livio Luongo; Stefania Dragoni; Alessia Ligresti; Avraham Rosenberg; Daniele Bolognini; Maria Grazia Cascio; Roger G Pertwee; Ruin Moaddel; Sabatino Maione; Vincenzo Di Marzo; Federico Corelli
Journal: ChemMedChem Date: 2012-03-02 Impact factor: 3.466

10. The tamoxifen derivative ridaifen-B is a high affinity selective CB₂ receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects.

Authors: Lirit N Franks; Benjamin M Ford; Toshifumi Fujiwara; Haibo Zhao; Paul L Prather
Journal: Toxicol Appl Pharmacol Date: 2018-06-12 Impact factor: 4.219

Cannabinoids in the treatment of cancer.

1. Mistic and TarCF as fusion protein partners for functional expression of the cannabinoid receptor 2 in Escherichia coli.

2. Cannabinoids attenuate cancer pain and proliferation in a mouse model.

3. Revisiting CB1 receptor as drug target in human melanoma.

4. Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

5. Cannabidiol inhibits angiogenesis by multiple mechanisms.

6. Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells.

7. Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.

Review 8. Mechanisms of Cannabinoids and Potential Applicability to Skin Diseases.

9. Endocannabinoid regulation in human endometrium across the menstrual cycle.

10. The tamoxifen derivative ridaifen-B is a high affinity selective CB₂ receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects.