Haodong Lin1, Chunlin Hou, Xianyou Zhen, Zhen Xu. 1. Department of Orthopedic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai, PR China.
Abstract
OBJECT: Neurogenic bladder dysfunction following spinal cord injury (SCI) is a major medical and social problem for which there is no ideal treatment strategy. In the present study, the authors analyze the effectiveness of neurogenic bladder reinnervation in patients with SCIs by using Achilles tendon reflexes below the paraplegic level. METHODS: Spinal root anastomoses were performed in 12 paraplegic patients with hyperreflexic neurogenic bladder and detrusor external sphincter dyssynergia (DESD) caused by complete suprasacral SCI, in an attempt to reinnervate the bladder. The surgery anastomosed the unilateral proximal end of the S-1 ventral root and the distal end of the S-2 and/or S-3 ventral roots to build the Achilles tendon-to-bladder reflex, while the S-1 dorsal root was kept intact as the trigger for micturition after axonal regeneration. All patients underwent urodynamic evaluation before surgery and at follow-up. RESULTS: The mean follow-up duration was 3 years. Of the 12 patients, 9 (75%) regained satisfactory bladder control within 6 to 12 months after ventral root microanastomosis. In these 9 patients, urodynamic studies revealed a change from detrusor hyperreflexia with DESD and high detrusor pressure to almost normal storage and synergic voiding without DESD. The average bladder capacity increased from 258 +/- 33 ml to 350 +/- 49 ml, residual urine decreased from 214 +/- 36 ml to 45 +/- 11 ml, and urinary infections were not observed. Patients with impaired renal function experienced a full recovery. Three patients failed to show any improvement after the operation. CONCLUSIONS: These results suggest the effectiveness of bladder innervation below the level of SCI to produce urination by Achilles tendon-to-bladder reflex contractions, and might therefore provide a new clinical approach to reconstructing spasmodic bladder urination function.
OBJECT: Neurogenic bladder dysfunction following spinal cord injury (SCI) is a major medical and social problem for which there is no ideal treatment strategy. In the present study, the authors analyze the effectiveness of neurogenic bladder reinnervation in patients with SCIs by using Achilles tendon reflexes below the paraplegic level. METHODS: Spinal root anastomoses were performed in 12 paraplegic patients with hyperreflexic neurogenic bladder and detrusor external sphincter dyssynergia (DESD) caused by complete suprasacral SCI, in an attempt to reinnervate the bladder. The surgery anastomosed the unilateral proximal end of the S-1 ventral root and the distal end of the S-2 and/or S-3 ventral roots to build the Achilles tendon-to-bladder reflex, while the S-1 dorsal root was kept intact as the trigger for micturition after axonal regeneration. All patients underwent urodynamic evaluation before surgery and at follow-up. RESULTS: The mean follow-up duration was 3 years. Of the 12 patients, 9 (75%) regained satisfactory bladder control within 6 to 12 months after ventral root microanastomosis. In these 9 patients, urodynamic studies revealed a change from detrusor hyperreflexia with DESD and high detrusor pressure to almost normal storage and synergic voiding without DESD. The average bladder capacity increased from 258 +/- 33 ml to 350 +/- 49 ml, residual urine decreased from 214 +/- 36 ml to 45 +/- 11 ml, and urinary infections were not observed. Patients with impaired renal function experienced a full recovery. Three patients failed to show any improvement after the operation. CONCLUSIONS: These results suggest the effectiveness of bladder innervation below the level of SCI to produce urination by Achilles tendon-to-bladder reflex contractions, and might therefore provide a new clinical approach to reconstructing spasmodic bladder urination function.
Authors: Ornella Lam Van Ba; Mary F Barbe; Romain Caremel; Shachar Aharony; Oleg Loutochin; Line Jacques; Matthew W Wood; Ekta Tiwari; Gerald F Tuite; Lysanne Campeau; Jacques Corcos; Michael R Ruggieri Journal: Neurourol Urodyn Date: 2018-01-04 Impact factor: 2.696
Authors: Sandra M Gomez-Amaya; Mary F Barbe; William C de Groat; Justin M Brown; Gerald F Tuite; Jacques Corcos; Susan B Fecho; Alan S Braverman; Michael R Ruggieri Journal: Nat Rev Urol Date: 2015-02 Impact factor: 14.432