Literature DB >> 19441011

Bioassay-guided isolation of apigenin with GABA-benzodiazepine activity from Tanacetum parthenium.

A K Jäger1, K Krydsfeldt, H B Rasmussen.   

Abstract

Extracts of Tanacetum parthenium are used in the prophylactic treatment of migraine and have also been used in Danish folk medicine for the treatment of epilepsy. An ethanol extract of T. parthenium showed high affinity for the GABA(A)-benzodiazepine site. An ethanol extract of T. parthenium was fractionated by VLC on silica and preparative C18 HPLC. Each step was monitored with the GABA(A)-benzodiazepine bioassay. The fractionation led to the isolation of apigenin, which may be responsible for CNS-effects of T. parthenium extracts.

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Year:  2009        PMID： 19441011     DOI： 10.1002/ptr.2816

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


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