Mostafa Metwally1, Sotirios H Saravelos, William L Ledger, Tin Chiu Li. 1. The Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield and Sheffield Teaching Hospitals, The Jessop Wing, Sheffield, United Kingdom. m.metwally@sheffield.ac.uk
Abstract
OBJECTIVE: To investigate the effect of underweight, overweight, and obesity on the risk of miscarriage in the subsequent pregnancy in women with recurrent miscarriage. DESIGN: Retrospective analysis of prospectively collected data from the database of a tertiary recurrent miscarriage center. SETTING: The recurrent miscarriage clinic at Sheffield Teaching Hospitals. PATIENT(S): A total of 844 pregnancies from 491 patients with recurrent miscarriage were included in the analysis. MAIN OUTCOME MEASURE(S): The odds of miscarriage in the subsequent pregnancy for all pregnancies after referral to the recurrent miscarriage clinic as well as the first pregnancy post referral. RESULT(S): When analyzing all pregnancies, and compared to women with a normal body mass index, obese and underweight patients had a significantly higher odds of miscarriage in the subsequent pregnancy (OR, 1.71; 95% CI, 1.05-2.8; and OR, 3.98; 95% CI, 1.06-14.92; respectively), whereas there was no significantly increased odds of miscarriage in overweight women (OR, 1.02; 95% CI, 0.72-1.45). Logistic regression analysis showed that the most important factor predicting the occurrence of miscarriage was advanced maternal age (P=0.01) followed by an increased body mass index (P=0.04). CONCLUSION(S): In women with recurrent miscarriage, a mild increase in the body mass index does not increase the risk of miscarriage, whereas obese and underweight patients have a small but significant increased risk of miscarriage in the subsequent pregnancy. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To investigate the effect of underweight, overweight, and obesity on the risk of miscarriage in the subsequent pregnancy in women with recurrent miscarriage. DESIGN: Retrospective analysis of prospectively collected data from the database of a tertiary recurrent miscarriage center. SETTING: The recurrent miscarriage clinic at Sheffield Teaching Hospitals. PATIENT(S): A total of 844 pregnancies from 491 patients with recurrent miscarriage were included in the analysis. MAIN OUTCOME MEASURE(S): The odds of miscarriage in the subsequent pregnancy for all pregnancies after referral to the recurrent miscarriage clinic as well as the first pregnancy post referral. RESULT(S): When analyzing all pregnancies, and compared to women with a normal body mass index, obese and underweight patients had a significantly higher odds of miscarriage in the subsequent pregnancy (OR, 1.71; 95% CI, 1.05-2.8; and OR, 3.98; 95% CI, 1.06-14.92; respectively), whereas there was no significantly increased odds of miscarriage in overweight women (OR, 1.02; 95% CI, 0.72-1.45). Logistic regression analysis showed that the most important factor predicting the occurrence of miscarriage was advanced maternal age (P=0.01) followed by an increased body mass index (P=0.04). CONCLUSION(S): In women with recurrent miscarriage, a mild increase in the body mass index does not increase the risk of miscarriage, whereas obese and underweight patients have a small but significant increased risk of miscarriage in the subsequent pregnancy. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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