Literature DB >> 19438554

Perilesional treatment of metastatic melanoma with interferon-beta.

T Fujimura1, R Okuyama, T Ohtani, Y Ito, T Haga, A Hashimoto, S Aiba.   

Abstract

Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)-beta for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-beta injection. These results suggest that the peritumoral administration of IFN-beta enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.

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Year:  2009        PMID： 19438554     DOI： 10.1111/j.1365-2230.2009.03207.x

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN： 0307-6938            Impact factor:   3.470


  11 in total

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Authors:  Malcolm Hart Squires; Keith A Delman
Journal:  Curr Oncol Rep       Date:  2013-10       Impact factor: 5.075

2.  Basal cell carcinoma with spontaneous regression: a case report and immunohistochemical study.

Authors:  Taku Fujimura; Aya Kakizaki; Yumi Kambayashi; Setsuya Aiba
Journal:  Case Rep Dermatol       Date:  2012-06-05

3.  Cutaneous lymphadenoma: a case report and immunohistochemical study.

Authors:  Taku Fujimura; Aya Itoigawa; Takahiro Haga; Setsuya Aiba
Journal:  Case Rep Dermatol       Date:  2012-03-01

Review 4.  Significance of Immunosuppressive Cells as a Target for Immunotherapies in Melanoma and Non-Melanoma Skin Cancers.

Authors:  Taku Fujimura; Setsuya Aiba
Journal:  Biomolecules       Date:  2020-07-22

Review 5.  Treatment of Advanced Melanoma: Past, Present and Future.

Authors:  Taku Fujimura; Yumi Kambayashi; Kentaro Ohuchi; Yusuke Muto; Setsuya Aiba
Journal:  Life (Basel)       Date:  2020-09-16

Review 6.  Stromal Factors as a Target for Immunotherapy in Melanoma and Non-Melanoma Skin Cancers.

Authors:  Taku Fujimura
Journal:  Int J Mol Sci       Date:  2022-04-06       Impact factor: 5.923

7.  Profiles of tumor-infiltrating lymphocytes in a case of trichilemmal carcinoma with spontaneous regression.

Authors:  Sadanori Furudate; Taku Fujimura; Akira Tsukada; Yukikazu Numata; Yumi Kambayashi; Setsuya Aiba
Journal:  Case Rep Dermatol       Date:  2012-10-16

8.  Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages.

Authors:  Aya Kakizaki; Taku Fujimura; Sadanori Furudate; Yumi Kambayashi; Takeshi Yamauchi; Hideo Yagita; Setsuya Aiba
Journal:  Oncoimmunology       Date:  2015-05-26       Impact factor: 8.110

Review 9.  Type I interferons: key players in normal skin and select cutaneous malignancies.

Authors:  Aimen Ismail; Nabiha Yusuf
Journal:  Dermatol Res Pract       Date:  2014-01-05

10.  Phase I study of nivolumab combined with IFN-β for patients with advanced melanoma.

Authors:  Taku Fujimura; Takanori Hidaka; Yumi Kambayashi; Sadanori Furudate; Aya Kakizaki; Hisayuki Tono; Akira Tsukada; Takahiro Haga; Akira Hashimoto; Ryo Morimoto; Takuhiro Yamaguchi; Tadao Takano; Setsuya Aiba
Journal:  Oncotarget       Date:  2017-04-13
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