Literature DB >> 19437524

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.

Boris Brumshtein1, Matilde Aguilar-Moncayo, M Isabel García-Moreno, Carmen Ortiz Mellet, José M García Fernández, Israel Silman, Yoseph Shaaltiel, David Aviezer, Joel L Sussman, Anthony H Futerman.   

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Year:  2009        PMID： 19437524     DOI： 10.1002/cbic.200900142

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  9 in total

1.  Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease.

Authors:  Susan D Orwig; Yun Lei Tan; Neil P Grimster; Zhanqian Yu; Evan T Powers; Jeffery W Kelly; Raquel L Lieberman
Journal:  Biochemistry       Date:  2011-11-14       Impact factor: 3.162

2.  1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines.

Authors:  Richard F G Fröhlich; Richard H Furneaux; Don J Mahuran; Brigitte A Rigat; Arnold E Stütz; Michael B Tropak; Jacqueline Wicki; Stephen G Withers; Tanja M Wrodnigg
Journal:  Carbohydr Res       Date:  2010-04-24       Impact factor: 2.104

3.  Fluorous iminoalditols: a new family of glycosidase inhibitors and pharmacological chaperones.

Authors:  Georg Schitter; Andreas J Steiner; Gerit Pototschnig; Elisabeth Scheucher; Martin Thonhofer; Chris A Tarling; Stephen G Withers; Katrin Fantur; Eduard Paschke; Don J Mahuran; Brigitte A Rigat; Michael B Tropak; Carina Illaszewicz; Robert Saf; Arnold E Stütz; Tanja M Wrodnigg
Journal:  Chembiochem       Date:  2010-09-24       Impact factor: 3.164

4.  A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

Authors:  Tomoko Takai; Katsumi Higaki; Matilde Aguilar-Moncayo; Teresa Mena-Barragán; Yuki Hirano; Kei Yura; Liang Yu; Haruaki Ninomiya; M Isabel García-Moreno; Yasubumi Sakakibara; Kousaku Ohno; Eiji Nanba; Carmen Ortiz Mellet; José M García Fernández; Yoshiyuki Suzuki
Journal:  Mol Ther       Date:  2013-01-22       Impact factor: 11.454

5.  Glycosylation is crucial for a proper catalytic site organization in human glucocerebrosidase.

Authors:  Laercio Pol-Fachin; Marina Siebert; Hugo Verli; Maria Luiza Saraiva-Pereira
Journal:  Glycoconj J       Date:  2016-03-29       Impact factor: 2.916

6.  Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase.

Authors:  Alen Sevšek; Javier Sastre Toraño; Linda Quarles van Ufford; Ed E Moret; Roland J Pieters; Nathaniel I Martin
Journal:  Medchemcomm       Date:  2017-10-10       Impact factor: 3.597

7.  1-Deoxy-D-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines.

Authors:  Richard F G Fröhlich; Richard H Furneaux; Don J Mahuran; Robert Saf; Arnold E Stütz; Michael B Tropak; Jacqueline Wicki; Stephen G Withers; Tanja M Wrodnigg
Journal:  Carbohydr Res       Date:  2011-05-24       Impact factor: 2.104

8.  A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C.

Authors:  Raquel L Lieberman
Journal:  Enzyme Res       Date:  2011-11-22

9.  Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

Authors:  Teresa Mena-Barragán; M Isabel García-Moreno; Alen Sevšek; Tetsuya Okazaki; Eiji Nanba; Katsumi Higaki; Nathaniel I Martin; Roland J Pieters; José M García Fernández; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2018-04-17       Impact factor: 4.411
  9 in total

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