Literature DB >> 19437452

Arsenic exposure induces genomic hypermethylation.

Sunipa Majumdar1, Sarmishtha Chanda, Bhaswati Ganguli, D N Guha Mazumder, Sarbari Lahiri, Uma B Dasgupta.   

Abstract

Gene-specific hypermethylation has previously been detected in Arsenic exposed persons. To monitor the level of whole genome methylation in persons exposed to different levels of Arsenic via drinking water, DNA was extracted from peripheral blood mononuclear cells of 64 persons. Uptake of methyl group from (3)H labeled S-Adenosyl Methionine after incubation of DNA with SssI methylase was measured. Results showed statistically significant (P = 0.0004) decrease in uptake of (3)H methyl group in the persons exposed to 250-500 microg/L arsenic, indicating genomic hypermethylation. (c) 2009 Wiley Periodicals, Inc.

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Year:  2010        PMID： 19437452     DOI： 10.1002/tox.20497

Source DB:  PubMed          Journal:  Environ Toxicol        ISSN： 1520-4081            Impact factor:   4.119


  31 in total

1.  Environmental chemical exposures and human epigenetics.

Authors:  Lifang Hou; Xiao Zhang; Dong Wang; Andrea Baccarelli
Journal:  Int J Epidemiol       Date:  2011-12-13       Impact factor: 7.196

2.  Extensive variation and low heritability of DNA methylation identified in a twin study.

Authors:  Kristina Gervin; Martin Hammerø; Hanne E Akselsen; Rune Moe; Heidi Nygård; Ingunn Brandt; Håkon K Gjessing; Jennifer R Harris; Dag E Undlien; Robert Lyle
Journal:  Genome Res       Date:  2011-09-26       Impact factor: 9.043

Review 3.  Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis.

Authors:  Jason Brocato; Max Costa
Journal:  Crit Rev Toxicol       Date:  2013-07       Impact factor: 5.635

Review 4.  Environmental epigenetics in metal exposure.

Authors:  Ricardo Martinez-Zamudio; Hyo Chol Ha
Journal:  Epigenetics       Date:  2011-07-01       Impact factor: 4.528

5.  Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life.

Authors:  Akhilesh Kaushal; Hongmei Zhang; Wilfried J J Karmaus; Todd M Everson; Carmen J Marsit; Margaret R Karagas; Shih-Fen Tsai; Hui-Ju Wen; Shu-Li Wang
Journal:  Environ Health       Date:  2017-05-30       Impact factor: 5.984

6.  Sodium arsenite delays the differentiation of C2C12 mouse myoblast cells and alters methylation patterns on the transcription factor myogenin.

Authors:  Amanda A Steffens; Gia-Ming Hong; Lisa J Bain
Journal:  Toxicol Appl Pharmacol       Date:  2010-10-18       Impact factor: 4.219

7.  DNA methylation of extracellular matrix remodeling genes in children exposed to arsenic.

Authors:  Tania Gonzalez-Cortes; Rogelio Recio-Vega; Robert Clark Lantz; Binh T Chau
Journal:  Toxicol Appl Pharmacol       Date:  2017-06-01       Impact factor: 4.219

8.  Blood methylomics in response to arsenic exposure in a low-exposed US population.

Authors:  Xin Liu; Yinan Zheng; Wei Zhang; Xiao Zhang; Donald M Lioyd-Jones; Andrea A Baccarelli; Hongyan Ning; Myriam Fornage; Ka He; Kiang Liu; Lifang Hou
Journal:  J Expo Sci Environ Epidemiol       Date:  2013-12-25       Impact factor: 5.563

9.  Arsenic exposure and DNA methylation among elderly men.

Authors:  Angeliki Lambrou; Andrea Baccarelli; Robert O Wright; Marc Weisskopf; Valentina Bollati; Chitra Amarasiriwardena; Pantel Vokonas; Joel Schwartz
Journal:  Epidemiology       Date:  2012-09       Impact factor: 4.822

Review 10.  Arsenic Exposure and Epigenetic Alterations: Recent Findings Based on the Illumina 450K DNA Methylation Array.

Authors:  Maria Argos
Journal:  Curr Environ Health Rep       Date:  2015-06
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