Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.

Literature DB >> 19437412

Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.

Susanne Pirker¹, Elisabeth Gasser, Thomas Czech, Christoph Baumgartner, Elisabeth Schuh, Martha Feucht, Klaus Novak, Fritz Zimprich, Günther Sperk.

Abstract

Dynorphin neuropeptides are believed to act as endogenous anticonvulsants, though direct evidence for such a role in humans is sparse. We now report pronounced increases of prodynorphin mRNA expression in the dentate gyrus of patients with temporal lobe epilepsy in comparison to controls. We detected a conspicuously right skewed, bimodal distribution of mRNA levels among patients, suggestive of a dynamic up-regulation of prodynorphin expression in epilepsy. Highest transcript levels were seen postictally. Our data argue for an essential role of dynorphin in the termination of seizures.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19437412 PMCID： PMC3073604 DOI： 10.1002/hipo.20633

Source DB: PubMed Journal: Hippocampus ISSN： 1050-9631 Impact factor: 3.899

19 in total

1. Opioid modulation of recurrent excitation in the hippocampal dentate gyrus.

Authors: G W Terman; C T Drake; M L Simmons; T A Milner; C Chavkin
Journal: J Neurosci Date: 2000-06-15 Impact factor: 6.167

2. An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression.

Authors: A Zimprich; J Kraus; M Wöltje; P Mayer; E Rauch; V Höllt
Journal: J Neurochem Date: 2000-02 Impact factor: 5.372

3. The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation.

Authors: M G Weisskopf; R A Zalutsky; R A Nicoll
Journal: Nature Date: 1993-04-01 Impact factor: 49.962

4. Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.

Authors: J J Wagner; G W Terman; C Chavkin
Journal: Nature Date: 1993-06-03 Impact factor: 49.962

5. Kappa opioid control of seizures produced by a virus in an animal model.

Authors: Marylou V Solbrig; Russell Adrian; Janie Baratta; Julie C Lauterborn; George F Koob
Journal: Brain Date: 2006-01-06 Impact factor: 13.501

6. Focal cortical release of endogenous opioids during reading-induced seizures.

Authors: M J Koepp; M P Richardson; D J Brooks; J S Duncan
Journal: Lancet Date: 1998-09-19 Impact factor: 79.321

7. Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.

Authors: Stephan Loacker; Mohammad Sayyah; Walter Wittmann; Herbert Herzog; Christoph Schwarzer
Journal: Brain Date: 2007-03-08 Impact factor: 13.501

Review 8. Neuropeptide Y: emerging evidence for a functional role in seizure modulation.

Authors: A Vezzani; G Sperk; W F Colmers
Journal: Trends Neurosci Date: 1999-01 Impact factor: 13.837

9. Upregulation of opioid receptor binding following spontaneous epileptic seizures.

Authors: Alexander Hammers; Marie-Claude Asselin; Rainer Hinz; Ian Kitchen; David J Brooks; John S Duncan; Matthias J Koepp
Journal: Brain Date: 2007-02-14 Impact factor: 13.501

10. Ancient and recent positive selection transformed opioid cis-regulation in humans.

Authors: Matthew V Rockman; Matthew W Hahn; Nicole Soranzo; Fritz Zimprich; David B Goldstein; Gregory A Wray
Journal: PLoS Biol Date: 2005-12 Impact factor: 8.029

10 in total

Review 1. Neuroanatomical clues to altered neuronal activity in epilepsy: from ultrastructure to signaling pathways of dentate granule cells.

Authors: Carolyn R Houser; Nianhui Zhang; Zechun Peng; Christine S Huang; Yliana Cetina
Journal: Epilepsia Date: 2012-06 Impact factor: 5.864

Review 2. Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment.

Authors: Nicole A Crowley; Thomas L Kash
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2015-01-12 Impact factor: 5.067

3. Glutamate decarboxylase 67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients.

Authors: Günther Sperk; Anna Wieselthaler-Hölzl; Susanne Pirker; Ramon Tasan; Sarah S Strasser; Meinrad Drexel; Christian Pifl; Julian Marschalek; Martin Ortler; Eugen Trinka; Katja Heitmair-Wietzorrek; Philippe Ciofi; Martha Feucht; Christoph Baumgartner; Thomas Czech
Journal: Hippocampus Date: 2011-04-20 Impact factor: 3.899

Review 4. Neuronal plasticity in animal models and the epileptic human hippocampus.

Authors: Gunther Sperk; Meinrad Drexel; Susanne Pirker
Journal: Epilepsia Date: 2009-12 Impact factor: 5.864

5. The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.

Authors: Luca Zangrandi; Johannes Burtscher; James P MacKay; William F Colmers; Christoph Schwarzer
Journal: Br J Pharmacol Date: 2016-04-21 Impact factor: 8.739

10. Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway.

Authors: Lin Liu; Yingtong Xu; Hongmei Dai; Shan Tan; Xiao Mao; Zhiheng Chen
Journal: Cell Biosci Date: 2020-03-17 Impact factor: 7.133