BACKGROUND: Clinical data and data on outcome of extra-osseous Ewing tumors are scarce. PROCEDURE: After a search for Ewing tumors in the database of a single institution over a period of 20 years, 16 out of 192 cases were found to have extra-osseous primary tumors. RESULTS: Ages at initial diagnosis ranged from 2.5 to 17 years. Follow-up period ranged from 4 months to 24.8 years (mean 8.4 years). Eleven patients were treated according to protocols for Ewing tumors, while in 4 cases soft tissue protocols were used. In a single patient only surgery was done. Two patients had progressive disease despite chemotherapy; a third patient had only tumor response on the initial 2 chemotherapy courses. All 3 patients with initially metastatic disease died. One patient developed a second malignancy. Overall survival at 5 years was 75%. Event-free survival (EFS) at 5 years was 68%; for nonmetastatic patients 5-year EFS was 83%. CONCLUSION: The authors conclude that nonmetastasized extra-osseous Ewing tumors have a prognosis at least similar to that of osseous Ewing tumors.
BACKGROUND: Clinical data and data on outcome of extra-osseous Ewing tumors are scarce. PROCEDURE: After a search for Ewing tumors in the database of a single institution over a period of 20 years, 16 out of 192 cases were found to have extra-osseous primary tumors. RESULTS: Ages at initial diagnosis ranged from 2.5 to 17 years. Follow-up period ranged from 4 months to 24.8 years (mean 8.4 years). Eleven patients were treated according to protocols for Ewing tumors, while in 4 cases soft tissue protocols were used. In a single patient only surgery was done. Two patients had progressive disease despite chemotherapy; a third patient had only tumor response on the initial 2 chemotherapy courses. All 3 patients with initially metastatic disease died. One patient developed a second malignancy. Overall survival at 5 years was 75%. Event-free survival (EFS) at 5 years was 68%; for nonmetastatic patients 5-year EFS was 83%. CONCLUSION: The authors conclude that nonmetastasized extra-osseous Ewing tumors have a prognosis at least similar to that of osseous Ewing tumors.
Authors: Mark A Applebaum; Jennifer Worch; Katherine K Matthay; Robert Goldsby; John Neuhaus; Daniel C West; Steven G Dubois Journal: Cancer Date: 2011-01-10 Impact factor: 6.860
Authors: Thomas Cash; Elizabeth McIlvaine; Mark D Krailo; Stephen L Lessnick; Elizabeth R Lawlor; Nadia Laack; Joel Sorger; Neyssa Marina; Holcombe E Grier; Linda Granowetter; Richard B Womer; Steven G DuBois Journal: Pediatr Blood Cancer Date: 2016-06-14 Impact factor: 3.167
Authors: Nicole J M Freling; Johannes H M Merks; Peerooz Saeed; Alfons J M Balm; Johannes Bras; Bradley R Pieters; Judit A Adam; Rick R van Rijn Journal: Pediatr Radiol Date: 2010-08-20
Authors: Augustine M Saiz; Alicia A Gingrich; Robert J Canter; Amanda R Kirane; Arta M Monjazeb; R Lor Randall; Steven W Thorpe Journal: Sarcoma Date: 2019-04-24
Authors: Oadi N Shrateh; Afnan W M Jobran; Haneen Owienah; Thaer Sweileh; Mohand Abulihya; Motaz A Natsheh; Nazeeh Abu-Dayyah Journal: Ann Med Surg (Lond) Date: 2022-09-21