Literature DB >> 19436231

Could the treatment of differentiated thyroid carcinoma with 3.7 and 5.55 GBq of (131I)NaI, on an outpatient basis, be safe?

José Willegaignon de Amorim de Carvalho1, Marcelo Sapienza, Carla Ono, Tomoco Watanabe, Maria Inês Guimarães, Ricardo Gutterres, Maria Helena Marechal, Carlos Buchpiguel.   

Abstract

OBJECTIVES: The first objective of this study was to evaluate the radiological impact on relatives and the environment because of outpatient treatment of differentiated thyroid carcinoma with 3.7 and 5.55 GBq of (131I)NaI. The second objective was to determine, analyze, and evaluate whole-body radiation dose to caregivers, the production of contaminated solid waste, and the potentiality of radiation dose and surface contamination existing inside patients' households.
METHODS: Twenty patients were treated on an outpatient basis, taking into consideration their acceptable living conditions, interests, and willingness to comply with medical and radiation-safety guidelines. The caregivers themselves, as well as the potentiality of the radiation dose inside patients' residences, were monitored with a thermo-luminescence dosimeter. Surface contamination and contaminated solid wastes were identified and measured by using a Geiger-Müller detector. RESULTS AND DISCUSSION: Twenty-six monitored individuals received accumulated effective radiation doses of less than 1.0 mSv, and only one 2.8 mSv, throughout the 7 days of measurement. The maximum registered value for the potential of radiation dose inside all living areas was 1.30 mSv. The monitored surface contamination inside patients' dwellings showed a mean value of 4.2 Bq/cm for all surfaces found to be contaminated. A total of 2.5 l of contaminated solid waste was generated by the patients with 3.33 MBq of all estimated activity.
CONCLUSION: This study revealed that the treatment of differentiated thyroid carcinoma with 3.7 and 5.55 GBq of (131I)NaI, on an outpatient basis, can be safe when overseen by qualified professionals and with an adapted radiation-protection guideline. Even considering the radioiodine activity level and the dosimetric methodology applied here, negligible human exposure and a nonmeasurable radiological impact to the human environment were found.

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Year:  2009        PMID: 19436231     DOI: 10.1097/MNM.0b013e32832b79bc

Source DB:  PubMed          Journal:  Nucl Med Commun        ISSN: 0143-3636            Impact factor:   1.690


  7 in total

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6.  Do Current Radiation Safety Guidelines allow the Safe Release of a Thyroid Cancer Patient after High-dose Radioiodine Therapy? An Indian Perspective.

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7.  Higher body weight and distant metastasis are associated with higher radiation exposure to the household environment from patients with thyroid cancer after radioactive iodine therapy.

Authors:  Sheng-Fong Kuo; Tsung-Ying Ho; Miaw-Jene Liou; Kun-Ju Lin; Ru-Chin Cheng; Sheng-Chieh Chan; Bie-Yui Huang; Soh-Ching Ng; Feng-Hsuan Liu; Hung-Yu Chang; Sheng-Hwu Hsieh; Kun-Chun Chiang; Huang-Yang Chen; Ta-You Lo; Chih-Lang Lin; Jen-Der Lin
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  7 in total

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