Literature DB >> 19435145

Enhanced anti-inflammatory effects of celecoxib from a transdermally applied nanoemulsion.

F Shakeel1, S Baboota, A Ahuja, J Ali, S Shafiq.   

Abstract

The aim of the present study was to evaluate the enhanced anti-inflammatory effects of celecoxib (CXB) from a transdermally applied nanoemulsion. The anti-inflammatory effects of an optimized nanoemulsion formulation were compared with those of conventional CXB gel and nanoemulsion gel on carrageenan-induced paw edema in rats. These tests were compared using the Dunnett test of one-way analysis of variance (ANOVA). The % inhibition value after 24 h application was significant for optimized formulation C2 (85.4%) compared with CXB gel and nanoemulsion gel (p < 0.05). These results suggest that nanoemulsions can be successfully used to enhance the anti-inflammatory effects of CXB.

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Year:  2009        PMID： 19435145

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  5 in total

1.  Montelukast potentiates the antiinflammatory effect of NSAIDs in the rat paw formalin model and simultaneously minimizes the risk of gastric damage.

Authors:  Sherien A Abdelhady; Mennatallah A Ali; Tamer A Al-Shafie; Ebtsam M Abdelmawgoud; Dalia M Yacout; Mahmoud M El-Mas
Journal:  Inflamm Res       Date:  2021-08-11       Impact factor: 4.575

2.  Preparation and in vivo evaluation of indomethacin loaded true nanoemulsions.

Authors:  Faiyaz Shakeel; Wafa Ramadan; Huda M Gargum; Rajinder Singh
Journal:  Sci Pharm       Date:  2009-11-23

3.  Effect of formulation variables on preparation of celecoxib loaded polylactide-co-glycolide nanoparticles.

Authors:  Dustin L Cooper; Sam Harirforoosh
Journal:  PLoS One       Date:  2014-12-12       Impact factor: 3.240

Review 4.  Topical Nano and Microemulsions for Skin Delivery.

Authors:  Christofori M R R Nastiti; Thellie Ponto; Eman Abd; Jeffrey E Grice; Heather A E Benson; Michael S Roberts
Journal:  Pharmaceutics       Date:  2017-09-21       Impact factor: 6.321

5.  Influence of the microwave technology on solid dispersions of mefenamic acid and flufenamic acid.

Authors:  Sultan Alshehri; Faiyaz Shakeel; Mohamed Ibrahim; Ehab Elzayat; Mohammad Altamimi; Gamal Shazly; Kazi Mohsin; Musaed Alkholief; Bader Alsulays; Abdullah Alshetaili; Abdulaziz Alshahrani; Bander Almalki; Fars Alanazi
Journal:  PLoS One       Date:  2017-07-31       Impact factor: 3.240
  5 in total

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