Wendy C Ziai1, John J Lewin. 1. Division of Neurosciences Critical Care, Department of Neurology and Anesthesiology-Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. weziai@jhmi.edu
Abstract
PURPOSE OF REVIEW: The aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis. RECENT FINDINGS: This article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central nervous system compartments and unanswered issues for this management approach. SUMMARY: Intraventricular administration of antimicrobials may be necessary in certain difficult- to- eradicate central nervous system infections. There is a significant need for clinical trials and management guidelines in this area.
PURPOSE OF REVIEW: The aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis. RECENT FINDINGS: This article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central nervous system compartments and unanswered issues for this management approach. SUMMARY: Intraventricular administration of antimicrobials may be necessary in certain difficult- to- eradicate central nervous system infections. There is a significant need for clinical trials and management guidelines in this area.
Authors: Allan R Tunkel; Rodrigo Hasbun; Adarsh Bhimraj; Karin Byers; Sheldon L Kaplan; W Michael Scheld; Diederik van de Beek; Thomas P Bleck; Hugh J L Garton; Joseph R Zunt Journal: Clin Infect Dis Date: 2017-03-15 Impact factor: 9.079
Authors: John J Lewin; Aaron M Cook; Cynthia Gonzales; David Merola; Ron Neyens; William J Peppard; Gretchen M Brophy; Lisa Kurczewski; Melissa Giarratano; Jason Makii; A Shaun Rowe; Eljim P Tesoro; Amber Zaniewski; Sarah Clark; Wendy C Ziai Journal: Neurocrit Care Date: 2019-06 Impact factor: 3.210