UNLABELLED: The proteins Ena/VASP (Enabled/Vasodilator-Stimulated Phosphoprotein) family is involved in the regulation of actin cytoskeleton which activity is very important for physiological tissue formation but is sometimes implied in pathological processes. In this study, we analyzed the immunohistochemical expression of Mammalian Ena (Mena), which is a member of this family, in the cervical intraepithelial neoplasia (CIN) and also in the cervical squamous cell carcinomas. We analyzed 30 cases with CIN (1, 2 and 3), and 10 squamous carcinomas. We used the EnVision system by LabVision. The Mena antibody, izotype mouse IgA, clone 21, provided by BD Biosciences. RESULTS: We observed that Mena was not expressed in the normal cervical squamous epithelium but its expression was increased in parallel with the increasing grade of CIN, with up-regulation upon transition to CIN3 and further to invasive carcinoma. This is the first study in the literature about Mena expression in cervical lesions.
UNLABELLED: The proteins Ena/VASP (Enabled/Vasodilator-Stimulated Phosphoprotein) family is involved in the regulation of actin cytoskeleton which activity is very important for physiological tissue formation but is sometimes implied in pathological processes. In this study, we analyzed the immunohistochemical expression of Mammalian Ena (Mena), which is a member of this family, in the cervical intraepithelial neoplasia (CIN) and also in the cervical squamous cell carcinomas. We analyzed 30 cases with CIN (1, 2 and 3), and 10 squamous carcinomas. We used the EnVision system by LabVision. The Mena antibody, izotype mouse IgA, clone 21, provided by BD Biosciences. RESULTS: We observed that Mena was not expressed in the normal cervical squamous epithelium but its expression was increased in parallel with the increasing grade of CIN, with up-regulation upon transition to CIN3 and further to invasive carcinoma. This is the first study in the literature about Mena expression in cervical lesions.
Authors: Evanthia T Roussos; Michele Balsamo; Shannon K Alford; Jeffrey B Wyckoff; Bojana Gligorijevic; Yarong Wang; Maria Pozzuto; Robert Stobezki; Sumanta Goswami; Jeffrey E Segall; Douglas A Lauffenburger; Anne R Bresnick; Frank B Gertler; John S Condeelis Journal: J Cell Sci Date: 2011-07-01 Impact factor: 5.285
Authors: Evanthia T Roussos; Sumanta Goswami; Michele Balsamo; Yarong Wang; Robert Stobezki; Esther Adler; Brian D Robinson; Joan G Jones; Frank B Gertler; John S Condeelis; Maja H Oktay Journal: Clin Exp Metastasis Date: 2011-04-12 Impact factor: 5.150
Authors: Evanthia T Roussos; Yarong Wang; Jeffrey B Wyckoff; Rani S Sellers; Weigang Wang; Jiufeng Li; Jeffrey W Pollard; Frank B Gertler; John S Condeelis Journal: Breast Cancer Res Date: 2010-11-25 Impact factor: 6.466
Authors: Michele Balsamo; Chandrani Mondal; Guillaume Carmona; Leslie M McClain; Daisy N Riquelme; Jenny Tadros; Duan Ma; Eliza Vasile; John S Condeelis; Douglas A Lauffenburger; Frank B Gertler Journal: Sci Rep Date: 2016-10-17 Impact factor: 4.379