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Literature DB >> 19433912

Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.

Abstract

Factor XI (FXI) deficiency is a hereditary coagulation disorder observed in various mammalian species. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene. Because the disorder seems to have an impact on reproductive traits and udder health in cattle, we tested 103 randomly selected cows, 28 cows with repeat breeding, and 9 cows with recurrent mastitis for the presence of an abnormal FXI allele. Three related cows were diagnosed as carriers.

Entities: Disease Gene Species

Mesh：

Substances：
Factor XI

Year: 2009 PMID： 19433912 DOI： 10.1007/BF03195666

Source DB: PubMed Journal: J Appl Genet ISSN： 1234-1983 Impact factor: 3.240

12 in total

Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.

1. Factor XI (plasma thromboplastin antecedent) deficiency in cattle.

2. New hemophilia-like disease caused by deficiency of a third plasma thromboplastin factor.

3. Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency.

4. Factor XI mutation in a Holstein cow with repeat breeding in Japan.

5. Identification of factor XI deficiency in Holstein-Friesian cattle in Britain.

6. Canine factor XI (plasma thromboplastin antecedent) deficiency.

7. Bovine plasma thromboplastin antecedent (Factor XI) deficiency.

8. Identification of a mutation associated with factor XI deficiency in Holstein cattle.

9. Failure of Routine Coagulation Screening Tests to Detect Heterozygous State of Bovine Factor XI Deficiency.

10. Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency.

1. Novel identification of Factor XI deficiency in Indian Sahiwal (Bos indicus) cattle.