BACKGROUND: Paracoccidioidomycosis (PCM) is Latin America's most prevalent systemic mycosis, carrying an important social burden. Its agent, Paracoccidioides brasiliensis, has rarely been identified in nature. Studies characterizing acute/subacute PCM incidence and their relationship with climate variables are not available. This work analysed a series of acute/subacute cases that occurred in the Botucatu area, São Paulo State, Brazil, from 1969 to 1999, as an outcome of weather variability. METHODS: Stepwise regression of annual data was applied to model incidence, calculated based on 91 cases, from lagged variables: antecedent precipitation, air temperature, soil water storage, absolute and relative air humidity, and Southern Oscillation Index (SOI). RESULTS: Multiple regression analyses resulted in a model, which explains 49% of the incidence variance, taking into account the absolute air humidity in the year of exposure, soil water storage and SOI of the previous 2 years. CONCLUSIONS: The correlations may reflect enhanced fungal growth after increase in soil water storage in the longer term and greater spore release with increase in absolute air humidity in the short term.
BACKGROUND:Paracoccidioidomycosis (PCM) is Latin America's most prevalent systemic mycosis, carrying an important social burden. Its agent, Paracoccidioides brasiliensis, has rarely been identified in nature. Studies characterizing acute/subacute PCM incidence and their relationship with climate variables are not available. This work analysed a series of acute/subacute cases that occurred in the Botucatu area, São Paulo State, Brazil, from 1969 to 1999, as an outcome of weather variability. METHODS: Stepwise regression of annual data was applied to model incidence, calculated based on 91 cases, from lagged variables: antecedent precipitation, air temperature, soil water storage, absolute and relative air humidity, and Southern Oscillation Index (SOI). RESULTS: Multiple regression analyses resulted in a model, which explains 49% of the incidence variance, taking into account the absolute air humidity in the year of exposure, soil water storage and SOI of the previous 2 years. CONCLUSIONS: The correlations may reflect enhanced fungal growth after increase in soil water storage in the longer term and greater spore release with increase in absolute air humidity in the short term.
Authors: Silvio Alencar Marques; Joel Carlos Lastória; Rosangela Maria Pires de Camargo; Mariangela Esther Alencar Marques Journal: An Bras Dermatol Date: 2016 May-Jun Impact factor: 1.896
Authors: Diana Rodrigues de Pina; Matheus Alvarez; Guilherme Giacomini; Ana Luiza Menegatti Pavan; Carlos Ivan Andrade Guedes; Ricardo de Souza Cavalcante; Rinaldo Poncio Mendes; Anamaria Mello Miranda Paniago Journal: Quant Imaging Med Surg Date: 2017-06
Authors: Otavio Cabral-Marques; Lena-Friederike Schimke; Paulo Vítor Soeiro Pereira; Angela Falcai; João Bosco de Oliveira; Mary J Hackett; Paolo Ruggero Errante; Cristina Worm Weber; Janaíra Fernandes Ferreira; Gisele Kuntze; Nelson Augusto Rosário-Filho; Hans D Ochs; Troy R Torgerson; Beatriz Tavares Costa Carvalho; Antonio Condino-Neto Journal: J Clin Immunol Date: 2011-12-23 Impact factor: 8.317