Literature DB >> 19433364

Automated synthesis of n.c.a. [18F]FDOPA via nucleophilic aromatic substitution with [18F]fluoride.

B Shen1, W Ehrlichmann, M Uebele, H-J Machulla, G Reischl.   

Abstract

An improved, automated synthesis of [(18)F]FDOPA including four synthetic steps (fluorination, reductive iodination, alkylation and hydrolysis) is reported with each step optimized individually. In a home-made automatic synthesizer, 9064+/-3076 MBq of [(18)F]FDOPA were produced within 120 min from EOB (n=5). Radiochemical purity and enantiomeric excess were both >or= 95%. Specific activity was ca. 50 GBq/micromol at EOS. This automatically operable synthesis is well suited for the multi-patient-dose routine production of n.c.a. [(18)F]FDOPA.

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Year:  2009        PMID： 19433364     DOI： 10.1016/j.apradiso.2009.03.003

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  9 in total

1.  One-pot synthesis of high molar activity 6-[18F]fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor.

Authors:  Andrew V Mossine; Sean S Tanzey; Allen F Brooks; Katarina J Makaravage; Naoko Ichiishi; Jason M Miller; Bradford D Henderson; Marc B Skaddan; Melanie S Sanford; Peter J H Scott
Journal:  Org Biomol Chem       Date:  2019-09-19       Impact factor: 3.876

2.  Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [18F]-2-Fluorobenzoylaminohexanoicanilide.

Authors:  Robin Bonomi; Vadim Popov; Maxwell T Laws; David Gelovani; Anjoy Majhi; Aleksandr Shavrin; Xin Lu; Otto Muzik; Nashaat Turkman; Renshyan Liu; Thomas Mangner; Juri G Gelovani
Journal:  J Med Chem       Date:  2018-08-13       Impact factor: 7.446

3.  Syntheses of meta-[F]Fluorobenzaldehyde and meta-[F]Fluorobenzylbromide from Phenyl(3-Formylphenyl) Iodonium Salt Precursors.

Authors:  Falguni Basuli; Haitao Wu; Gary L Griffiths
Journal:  J Labelled Comp Radiopharm       Date:  2011-04       Impact factor: 1.921

4.  Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester without azeotropic drying of fluorine-18.

Authors:  Falguni Basuli; Xiang Zhang; Elaine M Jagoda; Peter L Choyke; Rolf E Swenson
Journal:  Nucl Med Biol       Date:  2016-08-30       Impact factor: 2.408

5.  Synthesis of high-molar-activity [18F]6-fluoro-L-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor.

Authors:  Andrew V Mossine; Sean S Tanzey; Allen F Brooks; Katarina J Makaravage; Naoko Ichiishi; Jason M Miller; Bradford D Henderson; Thomas Erhard; Christian Bruetting; Marc B Skaddan; Melanie S Sanford; Peter J H Scott
Journal:  Nat Protoc       Date:  2020-04-08       Impact factor: 13.491

Review 6.  6-[18F]fluoro-L-DOPA: a well-established neurotracer with expanding application spectrum and strongly improved radiosyntheses.

Authors:  M Pretze; C Wängler; B Wängler
Journal:  Biomed Res Int       Date:  2014-05-28       Impact factor: 3.411

7.  A Practical One-Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel-Mediated Radiofluorination.

Authors:  Boris D Zlatopolskiy; Johannes Zischler; Elizaveta A Urusova; Heike Endepols; Elena Kordys; Holm Frauendorf; Felix M Mottaghy; Bernd Neumaier
Journal:  ChemistryOpen       Date:  2015-05-07       Impact factor: 2.911

8.  Improved GMP-compliant multi-dose production and quality control of 6-[18F]fluoro-L-DOPA.

Authors:  G Luurtsema; H H Boersma; M Schepers; A M T de Vries; B Maas; R Zijlma; E F J de Vries; P H Elsinga
Journal:  EJNMMI Radiopharm Chem       Date:  2016-04-04

Review 9.  Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA.

Authors:  Ângela C B Neves; Ivanna Hrynchak; Inês Fonseca; Vítor H P Alves; Mariette M Pereira; Amílcar Falcão; Antero J Abrunhosa
Journal:  EJNMMI Radiopharm Chem       Date:  2021-03-10
  9 in total

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