| Literature DB >> 19433330 |
Margret Tuchscherer1, Ellen Kanitz, Birger Puppe, Armin Tuchscherer, Torsten Viergutz.
Abstract
The aim of the study was to determine the effects of a single social isolation (4h) of piglets on immediate changes in stress hormones and immune responses at 7, 21 or 35 days of age. This social stressor caused an increase in plasma ACTH and cortisol concentrations and a decrease in plasma TNF-alpha. The percentage of CD8+ cells increased and the CD4+ cell percentage decreased, resulting in decreasing CD4+/CD8+ ratio. The observed changes were consistent for all days studied. Further, the isolation treatment resulted in diminished LPS-stimulated IL-1beta and IL-10 production in whole-blood cultures. In isolated piglets, positive correlations were estimated between changes in percentage of CD8+ cells and cortisol, and negative ones between changes in plasma TNF-alpha and culture supernatant IL-1beta with ACTH and cortisol. The data suggest that psychosocial stress in neonatal pigs induced immune alterations to maintain adaptive stability, but reflecting also negative emotions experienced by this treatment.Entities:
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Year: 2009 PMID： 19433330 DOI： 10.1016/j.rvsc.2009.04.010
Source DB: PubMed Journal: Res Vet Sci ISSN： 0034-5288 Impact factor: 2.534