Literature DB >> 19433263

Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents.

Milan Jokanović1.   

Abstract

This study reviews current understanding of chemical, biochemical and toxicological aspects and mechanisms of metabolism of warfare nerve agents. Among enzymes participating in metabolism of nerve agents the role of A-esterases, serum cholinesterase and carboxylesterases is discussed. This article also discusses other aspects of metabolism of the agents such as protein binding and the role of tissue depots for these compounds.

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Year:  2009        PMID： 19433263     DOI： 10.1016/j.toxlet.2009.03.017

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  5 in total

1.  Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.

Authors:  Andrew C Hemmert; Tamara C Otto; Monika Wierdl; Carol C Edwards; Christopher D Fleming; Mary MacDonald; John R Cashman; Philip M Potter; Douglas M Cerasoli; Matthew R Redinbo
Journal:  Mol Pharmacol       Date:  2010-01-05       Impact factor: 4.436

2.  Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon.

Authors:  Shensheng Zhao; Sebastiaan Wesseling; Bert Spenkelink; Ivonne M C M Rietjens
Journal:  Arch Toxicol       Date:  2021-03-14       Impact factor: 5.153

3.  Advances in toxicology and medical treatment of chemical warfare nerve agents.

Authors:  Mohammd Moshiri; Emadodin Darchini-Maragheh; Mahdi Balali-Mood
Journal:  Daru       Date:  2012-11-28       Impact factor: 3.117

4.  Recent advances in the treatment of organophosphorous poisonings.

Authors:  Mahdi Balali-Mood; Hamidreza Saber
Journal:  Iran J Med Sci       Date:  2012-06

5.  Bioconcentration and Acute Intoxication of Brazilian Freshwater Fishes by the Methyl Parathion Organophosphate Pesticide.

Authors:  João Bosco de Salles; Renato Matos Lopes; Cristiane M C de Salles; Vicente P F Cassano; Manildo Marcião de Oliveira; Vera L F Cunha Bastos; Jayme Cunha Bastos
Journal:  Biomed Res Int       Date:  2015-08-03       Impact factor: 3.411
  5 in total

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