| Literature DB >> 1943162 |
Abstract
A methanolic fraction of a chloroform extract of defatted Pluchea indica roots was investigated for its antiinflammatory potential against several models of inflammation. The extract showed significant inhibitory activity against carrageenin-, histamine-, serotonin-, hyaluronidase- and sodium urate-induced pedal inflammation. The extract inhibited protein exudation and leucocyte migration. The extract also inhibited carrageenin- and cotton pellet-induced granuloma formation as well as turpentine-induced joint oedema and adjuvant-induced polyarthritis. The present observations establish the efficacy of the extract in the exudative, proliferative and chronic stages of inflammation.Entities:
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Year: 1991 PMID: 1943162 DOI: 10.1016/0378-8741(91)90172-a
Source DB: PubMed Journal: J Ethnopharmacol ISSN: 0378-8741 Impact factor: 4.360