Literature DB >> 19431586

Substituents at the c(13) position of retinal and their influence on the function of bacteriorhodopsin.

P Tavan, K Schulten, W Gärtner, D Oesterhelt.   

Abstract

Retinal analogues in which the 13-methyl group is replaced by H, C(2)H(5), CF(3), and OCH(3) residues are studied by means of quantumchemical modified neglect of diatomic overlap-correlated version (MNDOC) calculations. The analogues are suitable to test the stereochemical mechanism of proton pumping in bacteriorhodopsin. The results explain the proton-pumping activities of bacterio-opsin reconstituted with these analogues and elucidate the decisive role of retinal's ground-state intramolecular properties in the pump cycle of bacteriorhodopsin.

Entities:  

Year:  1985        PMID： 19431586      PMCID： PMC1435211          DOI： 10.1016/s0006-3495(85)83925-4

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  9 in total

1.  Red-absorbing visual pigment of butterflies.

Authors:  G D Bernard
Journal:  Science       Date:  1979-03-16       Impact factor: 47.728

2.  Reversible dissociation of the purple complex in bacteriorhodopsin and identification of 13-cis and all-trans-retinal as its chromophores.

Authors:  D Oesterhelt; M Meentzen; L Schuhmann
Journal:  Eur J Biochem       Date:  1973-12-17

3.  N-retinylidene-1-amino-2-propanol: a Schiff base analog for rhodopsin.

Authors:  J O Erickson; P E Blatz
Journal:  Vision Res       Date:  1968-10       Impact factor: 1.886

Review 4.  Bacteriorhodopsin and related pigments of halobacteria.

Authors:  W Stoeckenius; R A Bogomolni
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

5.  Specificity of the retinal binding site of bacteriorhodopsin: chemical and stereochemical requirements for the binding of retinol and retinal.

Authors:  T Schreckenbach; B Walckhoff; D Oesterhelt
Journal:  Biochemistry       Date:  1978-12-12       Impact factor: 3.162

6.  Isomeric composition of retinal chromophore in dark-adapted bacteriorhodopsin.

Authors:  A Maeda; T Iwasa; T Yoshizawa
Journal:  J Biochem       Date:  1977-12       Impact factor: 3.387

7.  Determination of retinal Schiff base configuration in bacteriorhodopsin.

Authors:  S O Smith; A B Myers; J A Pardoen; C Winkel; P P Mulder; J Lugtenburg; R Mathies
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

8.  Visual-pigment spectra: implications of the protonation of the retinal Schiff base.

Authors:  B Honig; A D Greenberg; U Dinur; T G Ebrey
Journal:  Biochemistry       Date:  1976-10-19       Impact factor: 3.162

9.  Dark-adapted bacteriorhodopsin contains 13-cis, 15-syn and all-trans, 15-anti retinal Schiff bases.

Authors:  G S Harbison; S O Smith; J A Pardoen; C Winkel; J Lugtenburg; J Herzfeld; R Mathies; R G Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205
  9 in total
  2 in total

1.  Evidence for a 13,14-cis cycle in bacteriorhodopsin.

Authors:  P Tavan; K Schulten
Journal:  Biophys J       Date:  1986-07       Impact factor: 4.033

2.  All-trans retinal constitutes the functional chromophore in Chlamydomonas rhodopsin.

Authors:  P Hegemann; W Gärtner; R Uhl
Journal:  Biophys J       Date:  1991-12       Impact factor: 4.033
  2 in total

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