Literature DB >> 194311

Angiotensin converting enzyme: induction by steroids in rabbit alveolar macrophages in culture.

J Friedland, C Setton, E Silverstein.   

Abstract

Dexamethasone and prednisone in physiologic range increased angiotensin converting enzyme 7- to 16-fold in comparison to control in 3 days at maximal stimulation (4 nM steroid) in rabbit alveolar macrophages in culture. The increase was inhibited by actinomycin D (0.1 microng/ml) and 1 micronM cycloheximide, suggesting that de novo transcription and enzyme synthesis are responsible for the increased enzyme activity. This result is evidence for a regulatory mechanism for angiotensin converting enzyme, which is important in blood pressure control.

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Year:  1977        PMID： 194311     DOI： 10.1126/science.194311

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Sarcoidosis and mononuclear phagocytes.

Authors:  J B Gee; P T Bodel; S K Zorn; L M Hinman; C A Stevens; R A Matthay
Journal:  Lung       Date:  1978       Impact factor: 2.584

2.  Multiple control of inflammation by glucocorticoids.

Authors:  M Di Rosa; A Calignano; R Carnuccio; A Ialenti; L Sautebin
Journal:  Agents Actions       Date:  1986-01

3.  Serum angiotensin-converting enzyme and lysosomal enzymes in asbestosis.

Authors:  M S Huuskonen; J Jävisalo; H Koskinen; H Kivistö
Journal:  Lung       Date:  1986       Impact factor: 2.584

4.  In vitro synthesis of angiotensin-converting enzyme by alveolar macrophages is increased in disseminated sarcoidosis.

Authors:  G Stanislas-Leguern; M Mordelet-Dambrine; D Dusser; M Huesca; J Chretien; G J Huchon
Journal:  Lung       Date:  1986       Impact factor: 2.584

5.  Angiotensin-converting enzyme activity in serum and bronchoalveolar lavage fluid after damage to the alveolo-capillary barrier in the human lung.

Authors:  R F De Jongh; W A De Backer; R Mohan; P G Jorens; F J van Overveld
Journal:  Intensive Care Med       Date:  1993       Impact factor: 17.440

6.  Human lung angiotensin converting enzyme. Purification and antibody preparation.

Authors:  J Friedland; E Silverstein; M Drooker; C Setton
Journal:  J Clin Invest       Date:  1981-04       Impact factor: 14.808

7.  Neuropeptide degrading enzymes in normal and inflamed human synovium.

Authors:  D A Walsh; P I Mapp; J Wharton; J M Polak; D R Blake
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307

8.  Transpulmonary pharmacokinetics of an ACE inhibitor (perindoprilat) in man.

Authors:  R J MacFadyen; K R Lees; J D Gemmill; W S Hillis; J L Reid
Journal:  Br J Clin Pharmacol       Date:  1991-08       Impact factor: 4.335

9.  Induction by glucocorticoids of angiotensin converting enzyme production from bovine endothelial cells in culture and rat lung in vivo.

Authors:  F A Mendelsohn; C J Lloyd; C Kachel; J W Funder
Journal:  J Clin Invest       Date:  1982-09       Impact factor: 14.808

10.  Lung inflammation in sarcoidosis: comparison of serum angiotensin-converting enzyme levels with bronchoalveolar lavage and gallium-67 scanning assessment of the T lymphocyte alveolitis.

Authors:  C I Schoenberger; B R Line; B A Keogh; G W Hunninghake; R G Crystal
Journal:  Thorax       Date:  1982-01       Impact factor: 9.139
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