| Literature DB >> 19431018 |
Li-Jun Wang1, Xiao-Li Ye, Zhu Chen, Xue-Gang Li, Qing-Lei Sun, Bao-Shun Zhang, Xiao-Gang Cao, Gang Yu, Xiao-Hua Niu.
Abstract
By introducing octyloxy to C-3 and alkyl groups to C-8 of jatrorrhizine, a series of 3-octyloxy-8-alkyljatrorrhizine derivatives were synthesized and their antimicrobial activities were evaluated in vitro. The results indicated that the derivatives exhibited high antimicrobial activities, especially against Gram-positive bacteria. The 3-octyloxy-8-butyljatrorrhizine displayed the highest antimicrobial activity in all compounds. Their structure-activity relationships were discussed.Entities:
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Year: 2009 PMID： 19431018 DOI： 10.1080/10286020902727447
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569