Literature DB >> 19430986

Epstein-Barr virus-positive diffuse large B-cell lymphoma carrying a t(9;14)(p13;q32) translocation.

Hitoshi Ohno1, Momoko Nishikori, Hironori Haga, Kotaro Isoda.   

Abstract

We, herein, report a 75-year-old man with lymphoma who initially presented with disseminated disease involving the lung, followed by temporal regression, and finally died of disease progression. Lymph-node biopsy showed a morphology of diffuse large B-cell lymphoma (DLBCL), containing CD30(+) Reed-Sternberg-like cells. The lymphoma cells were stained by in situ hybridization (ISH) for Epstein-Barr virus (EBV)-encoded RNA, and the presence of the EBV genome was confirmed by the polymerase chain reaction. A cytogenetic study showed that the lymphoma cells carried a t(9;14)(p13;q32) translocation, and rearrangement of the PAX5 gene was determined by fluorescence ISH using a split signal probe. This case report is the first to identify t(9;14)(p13;q32) in EBV(+) DLBCL of the elderly, which was very recently listed among subtypes of DLBCL.

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Mesh：

Year:  2009        PMID： 19430986     DOI： 10.1007/s12185-009-0321-6

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  19 in total

1.  Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique.

Authors:  H Avet-Loiseau; A Daviet; C Brigaudeau; E Callet-Bauchu; C Terré; M Lafage-Pochitaloff; F Désangles; S Ramond; P Talmant; R Bataille
Journal:  Blood       Date:  2001-02-01       Impact factor: 22.113

2.  In vitro Epstein-Barr virus-immortalized lymphoma cell line carrying t(9;14)(p13;q32) chromosome abnormality, derived from splenic lymphoma with villous lymphocytes.

Authors:  Masanori Daibata; Takahiro Taguchi; Yuiko Nemoto; Shinji Iwasaki; Yuji Ohtsuki; Hirokuni Taguchi
Journal:  Int J Cancer       Date:  2006-01-15       Impact factor: 7.396

3.  Low-grade B-Cell lymphomas with plasmacytic differentiation lack PAX5 gene rearrangements.

Authors:  Tracy I George; Joanna E Wrede; Charles D Bangs; Athena M Cherry; Roger A Warnke; Daniel A Arber
Journal:  J Mol Diagn       Date:  2005-08       Impact factor: 5.568

4.  The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene.

Authors:  S Iida; P H Rao; P Nallasivam; H Hibshoosh; M Butler; D C Louie; V Dyomin; H Ohno; R S Chaganti; R Dalla-Favera
Journal:  Blood       Date:  1996-12-01       Impact factor: 22.113

5.  t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation.

Authors:  K Offit; N Z Parsa; D Filippa; S C Jhanwar; R S Chaganti
Journal:  Blood       Date:  1992-11-15       Impact factor: 22.113

6.  Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping.

Authors:  J R Sawyer; J L Lukacs; N Munshi; K R Desikan; S Singhal; J Mehta; D Siegel; J Shaughnessy; B Barlogie
Journal:  Blood       Date:  1998-12-01       Impact factor: 22.113

Review 7.  Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders: special references to lymphomas surrounding this newly recognized clinicopathologic disease.

Authors:  Yoshie Shimoyama; Kazuhito Yamamoto; Naoko Asano; Takashi Oyama; Tomohiro Kinoshita; Shigeo Nakamura
Journal:  Cancer Sci       Date:  2008-04-21       Impact factor: 6.716

8.  Posttransplantation lymphoproliferative disorders frequently contain type A and not type B Epstein-Barr virus.

Authors:  D Frank; E Cesarman; Y F Liu; R E Michler; D M Knowles
Journal:  Blood       Date:  1995-03-01       Impact factor: 22.113

9.  Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients.

Authors:  Takashi Oyama; Kazuhito Yamamoto; Naoko Asano; Aya Oshiro; Ritsuro Suzuki; Yoshitoyo Kagami; Yasuo Morishima; Kengo Takeuchi; Toshiyuki Izumo; Shigeo Mori; Koichi Ohshima; Junji Suzumiya; Naoya Nakamura; Masafumi Abe; Koichi Ichimura; Yumiko Sato; Tadashi Yoshino; Tomoki Naoe; Yoshie Shimoyama; Yoshikazu Kamiya; Tomohiro Kinoshita; Shigeo Nakamura
Journal:  Clin Cancer Res       Date:  2007-09-01       Impact factor: 12.531

10.  Epstein-Barr virus exploits BSAP/Pax5 to achieve the B-cell specificity of its growth-transforming program.

Authors:  Rosemary Tierney; Jasdeep Nagra; Isabel Hutchings; Claire Shannon-Lowe; Markus Altmann; Wolfgang Hammerschmidt; Alan Rickinson; Andrew Bell
Journal:  J Virol       Date:  2007-07-11       Impact factor: 5.103
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  4 in total

1.  Age-related EBV-associated lymphoproliferative disorders in the Western population: a spectrum of reactive lymphoid hyperplasia and lymphoma.

Authors:  Stefan D Dojcinov; Girish Venkataraman; Stefania Pittaluga; Iwona Wlodarska; Jeffrey A Schrager; Mark Raffeld; Robert K Hills; Elaine S Jaffe
Journal:  Blood       Date:  2011-03-08       Impact factor: 22.113

Review 2.  EBV-positive diffuse large B-cell lymphoma of the elderly.

Authors:  Chi Young Ok; Thomas G Papathomas; L Jeffrey Medeiros; Ken H Young
Journal:  Blood       Date:  2013-05-06       Impact factor: 22.113

3.  t(9;14)(p13;q32)/PAX5-IGH translocation as a secondary cytogenetic abnormality in diffuse large B-cell lymphoma.

Authors:  Hitoshi Ohno; Kayo Takeoka; Chiyuki Kishimori; Miho Nakagawa; Katsuhiro Fukutsuka; Fumiyo Maekawa; Masahiko Hayashida; Takashi Akasaka; Shinji Sumiyoshi
Journal:  J Clin Exp Hematop       Date:  2021-10-26

Review 4.  Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large B-cell lymphoma: a review of the literature.

Authors:  Carlos A Tirado; Weina Chen; Rolando García; Kelly A Kohlman; Nagesh Rao
Journal:  J Hematol Oncol       Date:  2012-09-11       Impact factor: 17.388
  4 in total

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